Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387066 | 0.75 | POLB (0.47) | POLBLMNAKMT2ATDP1P2RX7 | |
| SCHEMBL4394884 | 0.75 | POLB (0.47) | POLBLMNAKMT2ATDP1P2RX7 | |
| SCHEMBL4394887 | 0.75 | POLB (0.47) | POLBLMNAKMT2ATDP1P2RX7 | |
| SCHEMBL5893116 | 0.75 | RAB9A (0.44) | POLBLMNAKMT2ATDP1ALDH1A1 | |
| SCHEMBL4846135 | 0.74 | LRRK2 (0.53) | POLBLMNALRRK2ALDH1A1KDM4E | |
| SCHEMBL4846126 | 0.74 | LRRK2 (0.53) | POLBLMNALRRK2ALDH1A1KDM4E | |
| SCHEMBL4393129 | 0.73 | POLB (0.47) | POLBLMNAKMT2ATDP1P2RX7 | |
| SCHEMBL4393130 | 0.73 | POLB (0.47) | POLBLMNAKMT2ATDP1P2RX7 | |
| SCHEMBL4393133 | 0.73 | POLB (0.47) | POLBLMNAKMT2ATDP1P2RX7 | |
| SCHEMBL3050407 | 0.73 | MRGPRX4 (0.43) | POLBLMNAKMT2AP2RX7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268854-B2 | Aza-beta-carbolines and methods of using same | THE UWM RESEARCH FOUNDATION, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20090306121-A1 | AZA-BETA-CARBOLINES AND METHODS OF USING SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306121-A1 | AZA-BETA-CARBOLINES AND METHODS OF USING SAME | CHRNA7, CHRNA2, CHRNA5 | POLB 799/4885KCNA5 943/4885LMNA 1655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.