Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394700 | 0.88 | HRH4 (0.62) | HRH4HRH3NUDT1 | |
| SCHEMBL27738427 | 0.83 | HRH4 (0.69) | HRH4HRH3AURKA | |
| SCHEMBL2165477 | 0.83 | HRH4 (0.67) | HRH4HRH3 | |
| SCHEMBL27717385 | 0.82 | HRH4 (0.67) | HRH4HRH3AURKA | |
| SCHEMBL4395940 | 0.78 | HRH4 (0.57) | HRH4HRH3 | |
| SCHEMBL4397043 | 0.78 | HRH4 (0.52) | HRH4HRH3 | |
| SCHEMBL1774506 | 0.77 | HRH4 (0.71) | HRH4HRH3CYP1A2 | |
| SCHEMBL16822259 | 0.77 | HRH4 (0.67) | HRH4HRH3 | |
| SCHEMBL27717377 | 0.76 | HRH4 (0.67) | HRH4HRH3AURKA | |
| SCHEMBL28229132 | 0.76 | NUDT1 (0.61) | HRH4CYP1A2NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306038-A1 | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity | PALAU PHARMA, S.A. (ES) | 2009-12-10 | — | — | US | disclosed |
| EP-1928862-A1 | 2-AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR ACTIVITY | Palau Pharma, S.A. (ES) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007031529-A1 | 2-AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR ACTIVITY | PALAU PHARMA, S.A. (ES) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306038-A1 | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity | HRH4, HRH2, HRH3 | HRH4 1/4885HRH3 3/4885AURKA 1287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.