Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.62 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.56 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2165477 | 0.95 | HRH4 (0.67) | HRH4HTR3AHRH3 | |
| SCHEMBL28229132 | 0.88 | NUDT1 (0.61) | HRH4NUDT1 | |
| SCHEMBL4390422 | 0.88 | HRH4 (0.64) | HRH4HRH3NUDT1 | |
| SCHEMBL4397043 | 0.85 | HRH4 (0.52) | HRH4HRH3 | |
| SCHEMBL4395940 | 0.85 | HRH4 (0.57) | HRH4HRH3 | |
| SCHEMBL27738427 | 0.82 | HRH4 (0.69) | HRH4HRH3 | |
| SCHEMBL4401397 | 0.82 | HRH4 (0.91) | HRH4HRH3 | |
| SCHEMBL27738437 | 0.82 | AURKA (0.60) | HRH4HRH3 | |
| SCHEMBL27717385 | 0.82 | HRH4 (0.67) | HRH4HTR3AHRH3 | |
| SCHEMBL28736434 | 0.80 | PIK3CB (0.67) | HRH4NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306038-A1 | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity | PALAU PHARMA, S.A. (ES) | 2009-12-10 | — | — | US | disclosed |
| EP-1928862-A1 | 2-AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR ACTIVITY | Palau Pharma, S.A. (ES) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007031529-A1 | 2-AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR ACTIVITY | PALAU PHARMA, S.A. (ES) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306038-A1 | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity | HRH4, HRH2, HRH3 | HRH4 1/4885HTR3A 71/4885HRH3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.