Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.47 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.47 |
| ▸ | LAP3 | P28838 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15329288 | 0.98 | MAPT (0.54) | CA2CA1MAPTGPR84FFAR1 | |
| SCHEMBL28888733 | 0.88 | CA1 (0.47) | CA2CA1MAPTGPR84FFAR1 | |
| SCHEMBL21670103 | 0.87 | EPHX1 (0.48) | CA2CA1MAPTGPR84FFAR1 | |
| SCHEMBL16393900 | 0.87 | EPHX1 (0.48) | CA2CA1MAPTGPR84FFAR1 | |
| SCHEMBL7183545 | 0.87 | EPHX1 (0.48) | CA2CA1MAPTGPR84FFAR1 | |
| SCHEMBL31560160 | 0.87 | EPHX1 (0.48) | CA2CA1MAPTGPR84FFAR1 | |
| SCHEMBL30679515 | 0.87 | GPR84 (0.45) | CA2CA1MAPTGPR84FFAR1 | |
| SCHEMBL572638 | 0.85 | GPR84 (0.48) | CA2CA1MAPTGPR84FFAR1 | |
| SCHEMBL6901656 | 0.85 | SPHK1 (0.53) | CA2CA1MAPTGPR84FFAR1 | |
| SCHEMBL31057932 | 0.85 | EPHX1 (0.47) | CA2CA1MAPTGPR84FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2023939-A2 | COMPOUNDS AND METHODS FOR MODULATING EXPRESSION OF PCSK9 | Isis Pharmaceuticals, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007143315-A2 | COMPOUNDS AND METHODS FOR MODULATING EXPRESSION OF PCSK9 | ISIS PHARMACEUTICAL, INC. (US) | 2007-12-13 | — | — | WO | disclosed |