SCHEMBL439116

SCHEMBL439116

C#CCc1c(F)c(F)c(COC(=O)C2C(C=CC)C2(C)C)c(F)c1F

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
LMNA P02545 3/20 0.35
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
ADRA2A P08913 1/20 0.32
CNR1 P21554 1/20 0.32
ATM Q13315 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6901124 1.00 TDP1 (0.50) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL29843127 0.93 TDP1 (0.49) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL29843210 0.91 TDP1 (0.44) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL21959829 0.90 TDP1 (0.58) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL7583624 0.88 TDP1 (0.57) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL7583616 0.88 TDP1 (0.57) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL7584156 0.88 TDP1 (0.57) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL6898739 0.88 TDP1 (0.48) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL6902771 0.88 TDP1 (0.50) TDP1MEN1KMT2ALMNACYP1A2
SCHEMBL13810599 0.87 TDP1 (0.55) TDP1MEN1KMT2ALMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7459168-B2 Insecticide transpiration apparatus DAINIHON JOCHUGIKU CO., LTD. (JP) 2008-12-02 US claimed
EP-1352562-B1 Insecticide transpiration apparatus DAINIPPON JOCHUGIKU KK (JP) 2006-11-15 EP claimed
US-6926902-B2 Insecticide transpiration apparatus DAINHON JOCHUGIKU CO., LTD. (JP) 2005-08-09 US claimed
US-20040180070-A1 Insecticide transpiration apparatus DAINIHON JOCHUGIKU CO., LTD. (JP) 2004-09-16 US claimed
EP-1352562-A1 Insecticide transpiration apparatus DAINIHON JOCHUGIKU CO., LTD. (JP) 2003-10-15 EP claimed
US-20030160062-A1 Insecticide transpiration apparatus DAINIHON JOCHUGIKU CO., LTD. (JP) 2003-08-28 US claimed
US-9238078-B2 Modified-release pharmaceutical drug composition COATING PLACE, INC. (US) 2016-01-19 US disclosed
US-9125948-B2 Ion exchange resin treated to control swelling COATING PLACE, INC. (US) 2015-09-08 US disclosed
US-8883213-B2 Ion exchange resin treated to control swelling COATING PLACE, INC. (US) 2014-11-11 US disclosed
US-8343546-B2 Ion exchange resin treated to control swelling COATING PLACE, INC. (US) 2013-01-01 US disclosed
US-8329224-B2 Ion exchange resin treated to control swelling COATING PLACE, INC. (US) 2012-12-11 US disclosed
US-20120064167-A1 MODIFIED-RELEASE PHARMACEUTICAL DRUG COMPOSITION COATING PLACE, INC. (US) 2012-03-15 US disclosed
EP-2413898-A1 MODIFIED-RELEASE PHARMACEUTICAL DRUG COMPOSITION Coating Place, Inc. (US) 2012-02-08 EP disclosed
US-20070059270-A1 Loading one or more drugs in a solution onto one or more ion exchange resin particles to form a drug-loaded resin particle which is separated from the solution and dried before recombining the drug-loaded resin particle with the solution to load more drugs onto the drug-load; controlled release THE COATING PLACE, INC. (US) 2007-03-15 US disclosed
EP-1352562-B1 Insecticide transpiration apparatus DAINIPPON JOCHUGIKU KK (JP) 2006-11-15 EP disclosed
US-6926902-B2 Insecticide transpiration apparatus DAINHON JOCHUGIKU CO., LTD. (JP) 2005-08-09 US disclosed
US-20040180070-A1 Insecticide transpiration apparatus DAINIHON JOCHUGIKU CO., LTD. (JP) 2004-09-16 US disclosed
EP-1439163-A1 PROPARGYLBENZYL ALCOHOL ESTER DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND INSECTICIDE/INSECTIFUGE CONTAINING THE SAME DAINIHON JOCHUGIKU CO., LTD. (JP) 2004-07-21 EP disclosed
EP-1352562-A1 Insecticide transpiration apparatus DAINIHON JOCHUGIKU CO., LTD. (JP) 2003-10-15 EP disclosed
US-20030160062-A1 Insecticide transpiration apparatus DAINIHON JOCHUGIKU CO., LTD. (JP) 2003-08-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040180070-A1 Insecticide transpiration apparatus TIMM13, PIK3C3, ATP5PD TDP1 2733/4885MEN1 4117/4885KMT2A 3655/4885
US-20030160062-A1 Insecticide transpiration apparatus PIK3C3, ACHE, ATP5PD TDP1 1190/4885MEN1 4401/4885KMT2A 4329/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.