Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376027 | 0.89 | NPC1 (0.53) | NPC1LMNAALDH1A1MAPTUSP2 | |
| SCHEMBL4378240 | 0.86 | AR (0.44) | LMNAALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL4391637 | 0.76 | APP (0.60) | LMNAHPGDSMN1; SMN2KDM4EAPP | |
| SCHEMBL4382276 | 0.72 | NPC1 (0.55) | NPC1LMNAALDH1A1MAPTUSP2 | |
| SCHEMBL4378352 | 0.72 | ALDH1A1 (0.57) | NPC1LMNAALDH1A1MAPTUSP2 | |
| SCHEMBL4376233 | 0.71 | TSHR (0.51) | NPC1LMNAALDH1A1MAPTUSP2 | |
| SCHEMBL4379194 | 0.71 | ALDH1A1 (0.59) | NPC1LMNAALDH1A1MAPTUSP2 | |
| SCHEMBL14190919 | 0.70 | APP (0.74) | HPGDSMN1; SMN2KDM4EAPPMEN1 | |
| SCHEMBL4376030 | 0.70 | APP (0.74) | HPGDSMN1; SMN2KDM4EAPPMEN1 | |
| SCHEMBL2830259 | 0.70 | NPC1 (0.60) | NPC1LMNAALDH1A1MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |