Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | APP | P05067 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378352 | 0.93 | ALDH1A1 (0.57) | NPC1ALDH1A1USP2LMNAMAPT | |
| SCHEMBL4379194 | 0.92 | ALDH1A1 (0.59) | NPC1ALDH1A1USP2LMNAMAPT | |
| SCHEMBL4382276 | 0.80 | NPC1 (0.55) | NPC1ALDH1A1USP2LMNAMAPT | |
| SCHEMBL2830260 | 0.79 | APP (0.82) | ALDH1A1APPHPGDSMN1; SMN2KDM4E | |
| SCHEMBL4376027 | 0.79 | NPC1 (0.53) | NPC1ALDH1A1USP2LMNAMAPT | |
| SCHEMBL12381279 | 0.78 | L3MBTL3 (0.62) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL12381290 | 0.77 | L3MBTL3 (0.61) | ALDH1A1KDM4E | |
| SCHEMBL2829775 | 0.76 | ALDH1A1 (0.54) | NPC1ALDH1A1USP2LMNAMAPT | |
| SCHEMBL2829096 | 0.74 | ALDH1A1 (0.51) | NPC1ALDH1A1USP2LMNAMAPT | |
| SCHEMBL2831398 | 0.74 | ALDH1A1 (0.50) | NPC1ALDH1A1USP2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |