Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | BCL2 | P10415 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4385152 | 0.88 | LTA4H (0.32) | — | |
| SCHEMBL4386379 | 0.85 | KCNH2 (0.35) | KCNH2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4384690 | 0.81 | KCNH2 (0.34) | KCNH2MEN1KMT2A | |
| SCHEMBL4391999 | 0.77 | KCNH2 (0.34) | KCNH2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4392008 | 0.77 | KCNH2 (0.34) | KCNH2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4386375 | 0.74 | HRH3 (0.42) | HRH3 | |
| SCHEMBL4384666 | 0.74 | LTA4H (0.33) | KCNH2MEN1KMT2AHRH3 | |
| SCHEMBL4379690 | 0.73 | KMT2A (0.52) | KCNH2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7991191 | 0.71 | GAA (0.42) | MEN1NPC1RAB9AKMT2AHRH3 | |
| SCHEMBL4389355 | 0.70 | GPR84 (0.32) | KCNH2NPC1RAB9AGPR84HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |