SCHEMBL439222

SCHEMBL439222

Cc1oncc1C(=O)O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5593733 0.98 LMNA (0.51)
SCHEMBL29261172 0.98 LMNA (0.51)
Acetic Acid SCHEMBL28353986 0.96 LMNA (0.50)
SCHEMBL27318417 0.86 RAB9A (0.50)
SCHEMBL9395508 0.86 LMNA (0.43)
SCHEMBL27969576 0.84 LMNA (0.50)
SCHEMBL335045 0.82
4-Chloroaniline SCHEMBL11667673 0.82 RAB9A (0.43)
SCHEMBL11324067 0.82 RAB9A (0.44)
4-Bromoaniline SCHEMBL11664501 0.82 RAB9A (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 945 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118834382-A Preparation method of intrinsic antibacterial nylon based on end capping strategy 湘潭大学 2024-10-25 CN claimed
CN-116924938-A Preparation method of teriflunomide 江苏康缘药业股份有限公司 2023-10-24 CN claimed
EP-3672952-B1 BENZIMIDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS MERCK PATENT GMBH (DE) 2022-12-14 EP claimed
EP-3661941-B1 THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS MERCK PATENT GMBH (DE) 2022-12-14 EP claimed
US-20220306588-A1 BEZIMIDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS MERCK PATENT GMBH (DE) 2022-09-29 US claimed
US-11453647-B2 Benzimidazole derivatives as adenosine receptor antagonists MERCK PATENT GMBH (DE) 2022-09-27 US claimed
CN-110669022-B Micro-channel continuous preparation method of 5-methyl isoxazole-4-formic acid 常州沃腾化工科技有限公司 2022-03-11 CN claimed
US-11192899-B2 Quinoxaline derivatives as adenosine receptor antagonists MERCK PATENT GMBH (DE) 2021-12-07 US claimed
US-11186592-B2 Thiazolopyridine derivatives as adenosine receptor antagonists MERCK PATENT GMBH (DE) 2021-11-30 US claimed
CN-111233779-B Preparation method of leflunomide 廖文英 2021-08-20 CN claimed
US-20020022646-A1 Method for systhesizing leflunomide TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2002-02-21 US claimed
WO-2001098272-A1 NOVEL COMPOUNDS ASTRAZENECA AB (SE) 2001-12-27 WO claimed
WO-2001060363-A1 A METHOD FOR SYNTHESIZING LEFLUNOMIDE TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2001-08-23 WO claimed
US-5977151-A ANTITUMOR HOECHST AKTIENGESELLSCHAFT (DE) 1999-11-02 US claimed
CN-1189491-A Isoxazole and crotonamide derivatives and their use as pharmaceuticals and disgnositics HOECHST AG (DE) 1998-08-05 CN claimed
WO-1994024095-A1 IMMUNOSUPPRESSIVE AGENTS ABBOTT LABORATORIES (US) 1994-10-27 WO claimed
EP-0013376-B1 ISOXAZOLE DERIVATIVE, PROCESS FOR ITS PREPARATION AND COMPOSITION CONTAINING IT HOECHST AKTIENGESELLSCHAFT (DE) 1982-05-19 EP claimed
EP-0035285-A2 Novel isoxazole carboxylic acid phenyl esters, pharmaceutical compositions containing certain of said esters, and process for preparing said esters AMERICAN CYANAMID COMPANY (US) 1981-09-09 EP claimed
US-4284785-A ANTIINFLAMMATORY AGENTS AMERICAN CYANAMID COMPANY (US) 1981-08-18 US claimed
US-4087535-A ANALGESICS, ANTIINFLAMMATORY AGENTS HOECHST AKTIENGESELLSCHAFT (DT) 1978-05-02 US claimed