Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392504 | 0.98 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL5425044 | 0.94 | KDM4E (0.53) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4392507 | 0.90 | PDE4A (0.42) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4392574 | 0.90 | LMNA (0.52) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4171976 | 0.89 | KDM4E (0.48) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL3812661 | 0.88 | KDM4E (0.48) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4171969 | 0.87 | KDM4E (0.48) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4176225 | 0.86 | P2RY14 (0.43) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4389747 | 0.85 | PDE4A (0.45) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4176799 | 0.85 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628990-B1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-20070141276-A1 | Novel 14 and 15 membered ring compounds | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | US | disclosed |