Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 17/20 | 1.00 |
| ▸ | STK17B | O94768 | 2/20 | 0.51 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30320288 | 1.00 | NOTUM (1.00) | NOTUMSTK17BMAP3K8 | |
| SCHEMBL16333308 | 0.86 | NOTUM (0.76) | NOTUM | |
| SCHEMBL438084 | 0.85 | NOTUM (1.00) | NOTUMSTK17B | |
| SCHEMBL440706 | 0.82 | NOTUM (1.00) | NOTUMSTK17BMAP3K8 | |
| SCHEMBL441103 | 0.80 | NOTUM (1.00) | NOTUMSTK17BMAP3K8 | |
| SCHEMBL16333303 | 0.78 | NOTUM (0.74) | NOTUMSTK17BMAP3K8 | |
| SCHEMBL441163 | 0.75 | NOTUM (0.59) | NOTUM | |
| SCHEMBL16333597 | 0.74 | NOTUM (1.00) | NOTUMSTK17BMAP3K8 | |
| SCHEMBL438085 | 0.73 | NOTUM (0.77) | NOTUMMAP3K8 | |
| SCHEMBL439282 | 0.73 | NOTUM (0.56) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250092358-A1 | In Vitro Breeding Systems and Methods in Livestock | ABS GLOBAL, INC. (US) | 2025-03-20 | — | — | US | claimed |
| EP-4493275-A1 | METHODS AND COMPOSITIONS FOR IMPROVING IN VIVO SURVIVAL OF MIDBRAIN DOPAMINE NEURONS | Memorial Sloan Kettering Cancer Center (US) | 2025-01-22 | — | — | EP | claimed |
| US-20250017979-A1 | METHODS AND COMPOSITIONS FOR IMPROVING IN VIVO SURVIVAL OF MIDBRAIN DOPAMINE NEURONS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2025-01-16 | — | — | US | claimed |
| US-20240279601-A1 | METHODS OF GENERATING SACRAL NEURAL CREST LINEAGES AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2024-08-22 | — | — | US | claimed |
| EP-4355864-A1 | METHODS OF GENERATING SACRAL NEURAL CREST LINEAGES AND USES THEREOF | Memorial Sloan Kettering Cancer Center (US) | 2024-04-24 | — | — | EP | claimed |
| EP-4346395-A1 | IN VITRO BREEDING SYSTEMS AND METHODS IN LIVESTOCK | ABS Global, Inc. (US) | 2024-04-10 | — | — | EP | claimed |
| US-20240091254-A1 | WNT AGONISTS FOR PREVENTION OF CANCER | Stichting Amsterdam UMC (NL) | 2024-03-21 | — | — | US | claimed |
| EP-4322986-A1 | WNT AGONISTS FOR PREVENTION OF CANCER | Academisch Medisch Centrum (NL) | 2024-02-21 | — | — | EP | claimed |
| CN-117412668-A | Livestock in vitro breeding system and method | ABS全球公司 | 2024-01-16 | — | — | CN | claimed |
| WO-2023177919-A1 | METHODS AND COMPOSITIONS FOR IMPROVING IN VIVO SURVIVAL OF MIDBRAIN DOPAMINE NEURONS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2023-09-21 | — | — | WO | claimed |
| CN-115768875-A | Method for producing mesocerebral dopamine neurons, mesocerebral neurons and uses thereof | 纪念斯隆-凯特琳癌症中心 | 2023-03-07 | — | — | CN | claimed |
| EP-4127137-A1 | METHODS OF GENERATING MIDBRAIN DOPAMINE NEURONS, MIDBRAIN NEURONS AND USES THEREOF | Memorial Sloan Kettering Cancer Center (US) | 2023-02-08 | — | — | EP | claimed |
| WO-2022266527-A1 | METHODS OF GENERATING SACRAL NEURAL CREST LINEAGES AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2022-12-22 | — | — | WO | claimed |
| WO-2022251549-A1 | IN VITRO BREEDING SYSTEMS AND METHODS IN LIVESTOCK | ABS GLOBAL, INC. (US) | 2022-12-01 | — | — | WO | claimed |
| WO-2022219004-A1 | WNT AGONISTS FOR PREVENTION OF CANCER | ACADEMISCH MEDISCH CENTRUM (NL) | 2022-10-20 | — | — | WO | claimed |
| EP-2616471-B1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2014-12-31 | — | — | EP | claimed |
| US-20140288071-A1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | BARBOSA JOSEPH (US) | 2014-09-25 | — | — | US | claimed |
| EP-2616471-A1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2013-07-24 | — | — | EP | claimed |
| WO-2012037141-A1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2012-03-22 | — | — | WO | claimed |
| US-20120065200-A1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. | 2012-03-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065200-A1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | NOTUM, GLA, CES1 | NOTUM 1/4885STK17B 4180/4885MAP3K8 2640/4885 |
| US-20240279601-A1 | METHODS OF GENERATING SACRAL NEURAL CREST LINEAGES AND USES THEREOF | CHAT, ALPG, GFRA3 | NOTUM 3841/4885STK17B 2581/4885MAP3K8 2242/4885 |
| US-20140288071-A1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | NOTUM, GLA, CES1 | NOTUM 1/4885STK17B 4180/4885MAP3K8 2640/4885 |
| US-20250017979-A1 | METHODS AND COMPOSITIONS FOR IMPROVING IN VIVO SURVIVAL OF MIDBRAIN DOPAMINE NEURONS | CHAT, PINK1, DBH | NOTUM 4383/4885STK17B 1491/4885MAP3K8 1907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.