Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7250443 | 0.85 | GSK3B (0.56) | GSK3BMAPTNPC1ALDH1A1GAA | |
| SCHEMBL4404414 | 0.85 | GSK3B (0.55) | GSK3BMAPTNPC1PIK3CAPIK3CB | |
| SCHEMBL4972797 | 0.85 | GSK3B (0.47) | GSK3BMAPTNPC1ALDH1A1GAA | |
| SCHEMBL4393725 | 0.84 | GSK3B (0.75) | GSK3BMAPTNPC1ALDH1A1GAA | |
| SCHEMBL5091565 | 0.80 | GSK3B (0.58) | GSK3BMAPTNPC1ALDH1A1GAA | |
| SCHEMBL6112099 | 0.80 | PIK3CA (0.40) | GSK3BMAPTNPC1ALDH1A1GAA | |
| SCHEMBL5100050 | 0.78 | IDO1 (0.45) | GSK3BDPP4 | |
| SCHEMBL5101208 | 0.78 | GSK3B (0.58) | GSK3BMAPTNPC1ALDH1A1GAA | |
| SCHEMBL4970607 | 0.77 | GSK3B (0.55) | GSK3BMAPTNPC1ALDH1A1GAA | |
| SCHEMBL4398923 | 0.76 | GSK3B (0.55) | GSK3BMAPTNPC1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090074886-A1 | GSK-3 INHIBITORS | NOVARTIS VACCINES AND DIAGNOSTICS INC. | 2009-03-19 | — | — | US | disclosed |
| US-7425557-B2 | Inhibitors of glycogen synthase kinase 3 | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-16 | — | — | US | disclosed |
| EP-1490093-A4 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ISCHEMIA | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2007-04-11 | — | — | EP | disclosed |
| US-7045519-B2 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION (US) | 2006-05-16 | — | — | US | disclosed |
| US-7037918-B2 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION (US) | 2006-05-02 | — | — | US | disclosed |
| US-20060089369-A1 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION (US) | 2006-04-27 | — | — | US | disclosed |
| US-20050203059-A1 | Methods and compositions for treatment of ischemia | HARRISON STEPHEN D (US) | 2005-09-15 | — | — | US | disclosed |
| US-20050054663-A1 | Bone disorders; osteoporosis | CHIRON CORPORATION | 2005-03-10 | — | — | US | disclosed |
| EP-1490093-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ISCHEMIA | CHIRON CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-1087963-B1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORP (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003074072-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ISCHEMIA | CHIRON CORPORATION (US) | 2003-09-12 | — | — | WO | disclosed |
| US-20030130289-A1 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION | 2003-07-10 | — | — | US | disclosed |
| US-6489344-B1 | FOR TREATMENT DIABETES IN A HUMAN OR ANIMAL SUBJECT | CHIRON CORPORATION | 2002-12-03 | — | — | US | disclosed |
| US-20020156087-A1 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION | 2002-10-24 | — | — | US | disclosed |
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054663-A1 | Bone disorders; osteoporosis | GSK3B, GSK3A, GSKIP | GSK3B 1/4885MAPT 1221/4885NPC1 2893/4885 |
| US-20030130289-A1 | Inhibitors of glycogen synthase kinase 3 | GSK3B, GSK3A, PYGB | GSK3B 1/4885MAPT 134/4885NPC1 2111/4885 |
| US-20050203059-A1 | Methods and compositions for treatment of ischemia | PYGB, GSK3B, GSK3A | GSK3B 2/4885MAPT 737/4885NPC1 1801/4885 |
| US-20060089369-A1 | Inhibitors of glycogen synthase kinase 3 | GSK3B, GSK3A, PYGB | GSK3B 1/4885MAPT 146/4885NPC1 1941/4885 |
| US-20090074886-A1 | GSK-3 INHIBITORS | GSK3B, GSK3A, GSKIP | GSK3B 1/4885MAPT 594/4885NPC1 2867/4885 |
| US-20020156087-A1 | Inhibitors of glycogen synthase kinase 3 | GSK3B, GSK3A, PYGB | GSK3B 1/4885MAPT 146/4885NPC1 1941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.