Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4393669 | 1.00 | CA12 (0.42) | CA12CA14HSD17B10AKR1C3CA7 | |
| SCHEMBL13591208 | 0.89 | MEN1 (0.47) | CA12CA14HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL4673480 | 0.88 | MAPT (0.48) | CA12CA14SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4673477 | 0.88 | MAPT (0.48) | CA12CA14SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13392314 | 0.88 | ALDH1A1 (0.45) | CA12CA14HSD17B10SMN1; SMN2HTT | |
| SCHEMBL3309795 | 0.88 | MMP12 (0.43) | AKR1C3SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL13392207 | 0.88 | AKR1C3 (0.40) | CA14HSD17B10AKR1C3SMN1; SMN2LMNA | |
| SCHEMBL3309784 | 0.88 | MMP12 (0.43) | AKR1C3SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL13392309 | 0.85 | AKR1C3 (0.42) | CA12CA14HSD17B10AKR1C3CA7 | |
| SCHEMBL13409565 | 0.80 | AKR1C3 (0.42) | AKR1C3SMN1; SMN2LMNAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2128134-A1 | SULFONYLUREA DERIVATIVE CAPABLE OF SELECTIVELY INHIBITING MMP-13 | Shionogi&Co., Ltd. (JP) | 2009-12-02 | — | — | EP | disclosed |