SCHEMBL439437

SCHEMBL439437

NCC(=O)C(N)(CSSCC(N)(C(=O)O)C(=O)CN)C(=O)O

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.33
HIF1A Q16665 1/20 0.33
GLRA1 P23415 1/20 0.33
SLC6A9 P48067 1/20 0.33
OR51E2 Q9H255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9324958 1.00 SMN1; SMN2 (0.33) SMN1; SMN2HIF1AGLRA1SLC6A9OR51E2
SCHEMBL15757119 0.84 KIF11 (0.33)
SCHEMBL349825 0.78 GLRA1 (0.38) SMN1; SMN2HIF1AGLRA1SLC6A9OR51E2
SCHEMBL8819893 0.77 FFAR3 (0.36) SMN1; SMN2HIF1A
SCHEMBL8820876 0.75 GRM2 (0.34)
SCHEMBL4361740 0.74 MEN1 (0.39) SMN1; SMN2HIF1AGLRA1SLC6A9OR51E2
SCHEMBL121974 0.74 SMN1; SMN2 (0.34) SMN1; SMN2HIF1A
SCHEMBL3921490 0.74 SMN1; SMN2 (0.34) SMN1; SMN2HIF1A
SCHEMBL4223500 0.71 GSR (0.47)
SCHEMBL6937476 0.71 FAAH (0.47) OR51E2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1184038-B1 SYSTEM FOR RELEASE IN LOWER DIGESTIVE TRACT MOCHIDA PHARM CO LTD (JP) 2005-12-28 EP claimed
EP-1144613-B2 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY INC (US) 2020-05-06 EP disclosed
US-20170362626-A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY, INC. 2017-12-21 US disclosed
US-20160244798-A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY, INC. 2016-08-25 US disclosed
EP-2305804-B1 MonoPEGylated human growth hormone BOLDER BIOTECHNOLOGY INC (US) 2015-05-06 EP disclosed
EP-1799188-B1 USE OF PEPTIDES AS AN ANTIOXIDANT AGENT FOR THE PREPARATION OF A COSMETIC AND/OR PHARMACEUTICAL COMPOSITION ASHLAND SPECIALTIES FRANCE (FR) 2015-05-06 EP disclosed
US-8957023-B2 Methods for making proteins containing free cysteine residues BOLDER BIOTECHNOLOGY INC. (US) 2015-02-17 US disclosed
US-8932828-B2 Method for preparing recombinant granulocyte colony stimulating factor cysteine muteins BOLDER BIOTECHNOLOGY, INC. (US) 2015-01-13 US disclosed
US-8580159-B2 Ink for inkjet recording, ink set for inkjet recording, ink media set for inkjet recording, ink cartridge, inkjet recording method, and inkjet recording apparatus RICOH COMPANY, LTD. (JP) 2013-11-12 US disclosed
US-20130217629-A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY, INC. (US) 2013-08-22 US disclosed
WO-2001087925-A2 METHODS FOR REFOLDING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY, INC. (US) 2001-11-22 WO disclosed
EP-1144613-A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES Bolder Biotechnology, Inc. (US) 2001-10-17 EP disclosed
WO-2000042175-A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES BOLDER BIOTECHNOLOGY INC. (US) 2000-07-20 WO disclosed
EP-1001685-A1 NUTRITIONAL COMPOSITION CONTAINING METHIONINE N.V. Nutricia (NL) 2000-05-24 EP disclosed
WO-1999003365-A1 NUTRITIONAL COMPOSITION CONTAINING METHIONINE N.V. NUTRICIA (NL) 1999-01-28 WO disclosed
EP-0891719-A1 Nutritional composition containing methionine N.V. Nutricia (NL) 1999-01-20 EP disclosed
EP-0264953-B1 USE OF N,N'-BIS-L-AMINO ACID-L-CYSTIN PEPTIDES IN AMINO ACID PREPARATIONS FOR ORAL AND PARENTERAL ADMINISTRATION PFRIMMER KABI GMBH & CO. KG (DE) 1991-05-08 EP disclosed
US-4968696-A CHRONIC UREMIA OR HEPATIC CIRRHOSIS PFRIMMER + CO. PHARMAZEUTISCHE WERKE ERLANGEN GMBH + CO. KG (DE) 1990-11-06 US disclosed
WO-1988003150-A2 N,N'-BIS-AMINO ACID-L-CYSTINE-PEPTIDE-CONTAINING AMINO ACID PREPARATIONS FOR ORAL AND PARENTERAL ADMINISTRATION PFRIMMER + CO. PHARMAZEUTISCHE WERKE ERLANGEN GMBH (DE) 1988-05-05 WO disclosed
EP-0264953-A2 Use of N,N'-bis-L-amino acid-L-cystin peptides in amino acid preparations for oral and parenteral administration PFRIMMER KABI GMBH & CO. KG (DE) 1988-04-27 EP disclosed