SCHEMBL4394420

SCHEMBL4394420

COc1nccc(C(F)(F)F)c1S(=O)(=O)Nc1nc2c(OC)cnc(OC)n2n1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 1/20 0.39
AURKA O14965 1/20 0.34
KDR P35968 1/20 0.34
AURKB Q96GD4 1/20 0.34
CCR4 P51679 1/20 0.34
SCN9A Q15858 5/20 0.33
LRRK2 Q5S007 4/20 0.33
AXL P30530 5/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
ALOX15 P16050 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
CYP2C19 P33261 1/20 0.33
HSD17B10 Q99714 1/20 0.33
PTK2 Q05397 1/20 0.32
EGFR P00533 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6630344 0.85 CCR4 (0.37) SLC22A12CCR4SCN9ALRRK2AXL
SCHEMBL16359710 0.83 SLC22A12 (0.41) SLC22A12CCR4SCN9AAXLCYP1A2
SCHEMBL7864634 0.81 SLC22A12 (0.37) SLC22A12CCR4SCN9ALRRK2AXL
Penoxsulam SCHEMBL116968 0.81 PSEN1 (0.35) SLC22A12CCR4SCN9ACYP1A2CYP3A4
SCHEMBL7864594 0.81 SLC22A12 (0.37) SLC22A12CCR4SCN9ALRRK2AXL
SCHEMBL7860914 0.81 SLC22A12 (0.35) SLC22A12CCR4SCN9ACYP2C9
SCHEMBL7859430 0.80 KAT7 (0.38)
SCHEMBL7865966 0.80 SLC22A12 (0.34) SLC22A12KDRCCR4SCN9ACYP1A2
Penoxsulam SCHEMBL22587372 0.80 PSEN1 (0.34) SLC22A12KDRCCR4SCN9ACYP1A2
SCHEMBL17864073 0.79 SLC22A12 (0.34) SLC22A12KDRCCR4SCN9ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0877745-B1 N-( 1,2,4] TRIAZOLOAZINYL)BENZENESULFONAMIDE AND PYRIDINESULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2001-07-25 EP claimed
EP-1735309-B1 AN IMPROVED PROCESS FOR THE PREPARATION OF N-([1,2,4]TRIAZOLOPYRIMIDIN-2-YL)ARYL SULFONAMIDES DOW AGROSCIENCES LLC (US) 2009-12-09 EP disclosed
US-7339058-B2 Process for the preparation of N-([1,2,4]triazolopyrimidin-2-yl)aryl sulfonamides DOW AGROSCIENCES LLC (US) 2008-03-04 US disclosed
US-20050215570-A1 Process for the preparation of N-([1,2,4]triazolopyrimidin-2-yl)aryl sulfonamides CORTEVA AGRISCIENCE LLC 2005-09-29 US disclosed
CN-1159297-C N-([1,2,4]triazoleo azine group) benzene sulfonamide and pyridine sulfamide compound and their use as herbicide ��ũҵ��ѧ��˾ 2004-07-28 CN disclosed
CN-1397551-A N-([1,2,4]triazoleo azine group) benzene sulfonamide and pyridine sulfamide compound and their use as herbicide DOW AGROSCIENCES CORP (US) 2003-02-19 CN disclosed
CN-1092195-C N- ([1,2,4] triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC (US) 2002-10-09 CN disclosed
US-6303814-B1 N-[1,2,4]triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC 2001-10-16 US disclosed
US-6303814-B1 N-[1,2,4]triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC 2001-10-16 US disclosed
EP-0877745-B1 N-( 1,2,4] TRIAZOLOAZINYL)BENZENESULFONAMIDE AND PYRIDINESULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2001-07-25 EP disclosed
US-6130335-A N-([1,2,4]triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC (US) 2000-10-10 US disclosed
US-6130335-A N-([1,2,4]triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC (US) 2000-10-10 US disclosed
US-6005108-A POST-EMERGENCE TOTAL VEGETATION CONTROL OR SELECTIVE CONTROL OF WEEDS IN WHEAT, RICE AND OIL-SEED RAPE CROPS JOHNSON TIMOTHY C (US) 1999-12-21 US disclosed
US-6005108-A POST-EMERGENCE TOTAL VEGETATION CONTROL OR SELECTIVE CONTROL OF WEEDS IN WHEAT, RICE AND OIL-SEED RAPE CROPS JOHNSON TIMOTHY C (US) 1999-12-21 US disclosed
US-5965490-A NOVEL COMPOUNDS WITH IMPROVED SELECTIVITY TO VALUABLE CROPS AND IMPROVED TOXICOLOGICAL AND ENVIRONMENTAL ATTRIBUTES; APPLYING TO CONTROL WEEDS BY EITHER PREEMERGENCE OR POSTEMERGENCE APPLICATION DOW AGROSCIENCES LLC (US) 1999-10-12 US disclosed
US-5965490-A NOVEL COMPOUNDS WITH IMPROVED SELECTIVITY TO VALUABLE CROPS AND IMPROVED TOXICOLOGICAL AND ENVIRONMENTAL ATTRIBUTES; APPLYING TO CONTROL WEEDS BY EITHER PREEMERGENCE OR POSTEMERGENCE APPLICATION DOW AGROSCIENCES LLC (US) 1999-10-12 US disclosed
CN-1206416-A N- ([1,2,4] triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC (US) 1999-01-27 CN disclosed
US-5858924-A N-( 1, 2, 4! triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC (US) 1999-01-12 US disclosed
EP-0877745-A2 N-( 1,2,4] TRIAZOLOAZINYL)BENZENESULFONAMIDE AND PYRIDINESULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 1998-11-18 EP disclosed
WO-1998013367-A1 N-([1,2,4] TRIAZOLOAZINYL)BENZENESULFONAMIDE AND PYRIDINESULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 1998-04-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050215570-A1 Process for the preparation of N-([1,2,4]triazolopyrimidin-2-yl)aryl sulfonamides NISCH, CLIC4, CLIC1 SLC22A12 4186/4885AURKA 2388/4885KDR 3297/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.