Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 8/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 4/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.37 |
| ▸ | CYP2C18 | P33260 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255883 | 0.79 | CYP2C9 (0.52) | CYP2C9CYP2C8NTRK1CYP2C19CYP2C18 | |
| SCHEMBL4394717 | 0.73 | CYP2C9 (0.45) | CYP2C9CYP2C8NTRK1CYP2C19CYP2C18 | |
| SCHEMBL9453146 | 0.71 | SOAT1 (0.58) | CYP2C9CYP2C19CYP2C18POLBLMNA | |
| Propylamine SCHEMBL11088977 | 0.70 | CYP2C9 (0.44) | CYP2C9CYP2C8NTRK1CYP2C19CYP2C18 | |
| SCHEMBL11086699 | 0.70 | SOAT1 (0.60) | CYP2C9CYP2C19LMNATSHRNFKB1 | |
| SCHEMBL14973857 | 0.67 | CYP2C9 (0.48) | CYP2C9CYP2C8NTRK1CYP2C19CYP2C18 | |
| SCHEMBL7006506 | 0.66 | CYP2C9 (0.57) | CYP2C9CYP2C8NTRK1CYP2C19CYP2C18 | |
| SCHEMBL11274691 | 0.66 | CYP2C9 (0.57) | CYP2C9CYP2C8NTRK1CYP2C19CYP2C18 | |
| SCHEMBL20413716 | 0.65 | CYP2C9 (0.46) | CYP2C9CYP2C8NTRK1CYP2C19CYP2C18 | |
| SCHEMBL11226458 | 0.65 | ALDH1A1 (0.59) | CYP2C9NTRK1CYP2C19CYP2C18POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069571-A1 | Process for the Preparation of 5-Alkylthioalkylamino-I-Phenyl-Pyrazoles | MERIAL LIMITED | 2009-03-12 | — | — | US | claimed |
| US-20080281107-A1 | Process for the preparation of 5-alkylthioalkylamino-I-phenyl-pyrazoles | MERIAL LIMITED | 2008-11-13 | — | — | US | claimed |
| EP-1879869-A1 | PROCESS FOR THE PREPARATION OF 5-ALKYLTHIOALKYLAMINO-1-PHENYL-PYRAZOLES | Merial Limited (US) | 2008-01-23 | — | — | EP | claimed |
| WO-2006119862-A1 | PROCESS FOR THE PREPARATION OF 5-ALKYLTHIOALKYLAMINO-1-PHENYL-PYRAZOLES | MERIAL LTD. (US) | 2006-11-16 | — | — | WO | claimed |
| US-20090069571-A1 | Process for the Preparation of 5-Alkylthioalkylamino-I-Phenyl-Pyrazoles | MERIAL LIMITED | 2009-03-12 | — | — | US | disclosed |
| US-20090069571-A1 | Process for the Preparation of 5-Alkylthioalkylamino-I-Phenyl-Pyrazoles | MERIAL LIMITED | 2009-03-12 | — | — | US | disclosed |
| EP-1879869-B1 | PROCESS FOR THE PREPARATION OF PRECURSORS OF 5-ALKYLTHIOALKYLAMINO-1-PHENYL-PYRAZOLES | MERIAL LTD (US) | 2009-01-14 | — | — | EP | disclosed |
| US-20080281107-A1 | Process for the preparation of 5-alkylthioalkylamino-I-phenyl-pyrazoles | MERIAL LIMITED | 2008-11-13 | — | — | US | disclosed |
| US-20080281107-A1 | Process for the preparation of 5-alkylthioalkylamino-I-phenyl-pyrazoles | MERIAL LIMITED | 2008-11-13 | — | — | US | disclosed |
| EP-1879869-A1 | PROCESS FOR THE PREPARATION OF 5-ALKYLTHIOALKYLAMINO-1-PHENYL-PYRAZOLES | Merial Limited (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1879869-A1 | PROCESS FOR THE PREPARATION OF 5-ALKYLTHIOALKYLAMINO-1-PHENYL-PYRAZOLES | Merial Limited (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006119862-A1 | PROCESS FOR THE PREPARATION OF 5-ALKYLTHIOALKYLAMINO-1-PHENYL-PYRAZOLES | MERIAL LTD. (US) | 2006-11-16 | — | — | WO | disclosed |
| WO-2006119862-A1 | PROCESS FOR THE PREPARATION OF 5-ALKYLTHIOALKYLAMINO-1-PHENYL-PYRAZOLES | MERIAL LTD. (US) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080281107-A1 | Process for the preparation of 5-alkylthioalkylamino-I-phenyl-pyrazoles | CYP3A5, CYP1A1, CYP3A4 | CYP2C9 13/4885CYP2C8 42/4885NTRK1 2494/4885 |
| US-20090069571-A1 | Process for the Preparation of 5-Alkylthioalkylamino-I-Phenyl-Pyrazoles | CYP3A5, CYP1A1, CYP3A4 | CYP2C9 13/4885CYP2C8 42/4885NTRK1 2494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.