Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 2/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.41 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 3/20 | 0.38 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4391748 | 0.83 | HTR2C (0.44) | CSNK1DKDM4EPOLBMEN1NPC1 | |
| SCHEMBL4396146 | 0.77 | PIM1 (0.69) | CSNK1DNPC1PIK3CAGSK3BPIK3CD | |
| SCHEMBL4396147 | 0.77 | PIM1 (0.69) | CSNK1DNPC1PIK3CAGSK3BPIK3CD | |
| SCHEMBL30827802 | 0.76 | PIK3CA (0.60) | CSNK1DKDM4EPOLBMEN1NPC1 | |
| SCHEMBL732106 | 0.76 | PIK3CA (0.60) | CSNK1DKDM4EPOLBMEN1NPC1 | |
| SCHEMBL6627903 | 0.76 | TGFBR1 (0.67) | TGFBR1MAPK14PRKCIMETAP1CSNK1D | |
| SCHEMBL4194905 | 0.75 | CCNB2 (0.41) | TGFBR1CSNK1DKDM4EPOLBMEN1 | |
| SCHEMBL5328041 | 0.75 | KDM1A (0.51) | METAP1KDM4EPOLBALDH1A1KDM1A | |
| SCHEMBL4191687 | 0.74 | TOP2A (0.43) | TGFBR1MAPK14CSNK1DKDM4EPOLB | |
| SCHEMBL4196335 | 0.74 | ERN1 (0.45) | TGFBR1CSNK1DKDM4EPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306074-A1 | THIAZOLIDINEDIONE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2009-12-10 | — | — | US | disclosed |
| EP-2004189-A2 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | EP | disclosed |
| US-20080255115-A1 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | DARCY MICHAEL GERARD | 2008-10-16 | — | — | US | disclosed |
| WO-2007136940-A2 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255115-A1 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | PI4KA, JAK3, PIK3CD | TGFBR1 117/4885MAPK14 1480/4885PRKCI 273/4885 |
| US-20090306074-A1 | THIAZOLIDINEDIONE DERIVATIVES AS P13 KINASE INHIBITORS | JAK3, DPP3, ADRB3 | TGFBR1 132/4885MAPK14 918/4885PRKCI 229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.