Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 7/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2763863 | 0.75 | BCHE (0.45) | BCHEPHGDHMGLLPRKDCPIK3CA | |
| SCHEMBL10424259 | 0.69 | AKR1B1 (0.52) | BCHEKMT2ALMNA | |
| SCHEMBL11823082 | 0.68 | ALOX5 (0.42) | BCHEATMALDH1A1KMT2ALMNA | |
| SCHEMBL13113958 | 0.65 | BCHE (0.43) | BCHEPRKDCPIK3CAPIK3CBMTOR | |
| SCHEMBL2762764 | 0.65 | BCHE (0.43) | BCHEPRKDCPIK3CAPIK3CBMTOR | |
| SCHEMBL19357132 | 0.64 | PHGDH (1.00) | PHGDHMGLLALDH1A1KMT2ALMNA | |
| SCHEMBL11121684 | 0.64 | MAPT (0.56) | ALDH1A1KMT2ATSHRNPC1RAB9A | |
| SCHEMBL31061490 | 0.64 | BCHE (1.00) | BCHEALDH1A1KMT2ALMNATSHR | |
| SCHEMBL19380445 | 0.62 | HTT (0.48) | PHGDHMGLLALDH1A1KMT2ALMNA | |
| SCHEMBL4621432 | 0.62 | MGLL (0.53) | BCHEMGLLALDH1A1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485377-B1 | PYRANONES USEFUL AS ATM INHIBITORS | KUDOS PHARM LTD (GB) | 2009-12-09 | — | — | EP | disclosed |