Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.61 |
| ▸ | KDR | P35968 | 12/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 4/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | STK25 | O00506 | 1/20 | 0.45 |
| ▸ | CIT | O14578 | 1/20 | 0.45 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | MUSK | O15146 | 1/20 | 0.45 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382614 | 0.86 | PDGFRB (0.61) | PDGFRBFGFR1KDRKDM4EALDH1A1 | |
| SCHEMBL13041327 | 0.85 | FGFR1 (0.68) | PDGFRBFGFR1KDRKDM4EALDH1A1 | |
| SCHEMBL1249209 | 0.77 | DGAT1 (0.65) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL1251886 | 0.74 | DGAT1 (0.65) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL13041328 | 0.74 | FGFR1 (0.72) | PDGFRBFGFR1KDRFLT1CHEK1 | |
| SCHEMBL6387342 | 0.73 | PDGFRB (0.62) | PDGFRBFGFR1KDRL3MBTL1FLT1 | |
| SCHEMBL3381940 | 0.72 | FGFR1 (0.70) | PDGFRBFGFR1KDRFLT1CHEK1 | |
| SCHEMBL22955685 | 0.72 | HDAC6 (0.54) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL15911108 | 0.71 | FGFR1 (0.64) | PDGFRBFGFR1KDRFLT1CHEK1 | |
| SCHEMBL12834035 | 0.71 | KDM4E (0.73) | KDM4EALDH1A1LMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539754-A4 | BENZIMIDAZOLE QUINOLINONES AND USES THEREOF | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1539754-A2 | BENZIMIDAZOLE QUINOLINONES AND USES THEREOF | Chiron Corporation (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018419-A2 | BENZIMIDAZOLE QUINOLINONES AND USES THEREOF | CHIRON CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |