Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 3/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.63 |
| ▸ | RELA | Q04206 | 3/20 | 0.63 |
| ▸ | MOK | Q9UQ07 | 3/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4403005 | 0.91 | JUN (0.72) | JUNNFKB1NFKB2RELAMOK | |
| SCHEMBL4400432 | 0.90 | JUN (0.66) | JUNNFKB1NFKB2RELACHRNA7 | |
| SCHEMBL4400347 | 0.88 | JUN (0.65) | JUNNFKB1NFKB2RELAMOK | |
| SCHEMBL4395529 | 0.87 | JUN (0.61) | JUNNFKB1NFKB2RELAPRKDC | |
| SCHEMBL4393408 | 0.86 | JUN (0.74) | JUNNFKB1NFKB2RELAMAPT | |
| SCHEMBL4393330 | 0.86 | JUN (0.60) | JUNNFKB1NFKB2RELAPRKDC | |
| SCHEMBL4398262 | 0.85 | JUN (0.59) | JUNNFKB1NFKB2RELAPIK3CA | |
| SCHEMBL4394253 | 0.80 | JUN (0.62) | JUNNFKB1NFKB2RELAMAPT | |
| SCHEMBL4402986 | 0.80 | JUN (0.60) | JUNNFKB1NFKB2RELAPRKDC | |
| SCHEMBL4401463 | 0.80 | JUN (0.62) | JUNNFKB1NFKB2RELAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217037-B2 | Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2012-07-10 | — | — | US | disclosed |
| US-20090306073-A1 | Thiazole and Thiophene Analogues, and Their Use in Treating Autoimmune Diseases and Cancers | B.V. PATEL PHARMACEUTICAL EDUCATION & RESEARCH DEVELOPMENT (PERD) CENTRE (IN) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306073-A1 | Thiazole and Thiophene Analogues, and Their Use in Treating Autoimmune Diseases and Cancers | TPMT, TST, SSB | JUN 2228/4885NFKB1 1188/4885NFKB2 1441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.