Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | BCHE | P06276 | 5/20 | 0.50 |
| ▸ | ACHE | P22303 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SLC19A2 | O60779 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2177183 | 0.98 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1POLBRAB9ABCHE | |
| Hydrochloric Acid SCHEMBL3311343 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1POLBRAB9ABCHE | |
| SCHEMBL31482686 | 0.77 | RAB9A (0.67) | SMN1; SMN2NPC1POLBRAB9ABCHE | |
| SCHEMBL3603641 | 0.77 | NPC1 (0.96) | SMN1; SMN2NPC1POLBRAB9ABCHE | |
| SCHEMBL4890046 | 0.77 | NPC1 (0.96) | SMN1; SMN2NPC1POLBRAB9ABCHE | |
| SCHEMBL3600997 | 0.77 | NPC1 (0.96) | SMN1; SMN2NPC1POLBRAB9ABCHE | |
| SCHEMBL3606677 | 0.77 | NPC1 (0.96) | SMN1; SMN2NPC1POLBRAB9ABCHE | |
| SCHEMBL3598215 | 0.77 | NPC1 (0.96) | SMN1; SMN2NPC1POLBRAB9ABCHE | |
| SCHEMBL3592351 | 0.77 | NPC1 (0.96) | SMN1; SMN2NPC1POLBRAB9ABCHE | |
| SCHEMBL2860482 | 0.77 | RAB9A (0.67) | SMN1; SMN2NPC1POLBRAB9ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178678-B2 | Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-05-15 | — | — | US | disclosed |
| US-8178678-B2 | Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100069432-A1 | Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069432-A1 | Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | CHRNA2, CHRNA5, CHRNA4 | SMN1; SMN2 1447/4885NPC1 1844/4885POLB 3604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.