Hydroxyguanidine

Hydroxyguanidine

SCHEMBL961747

NC(N)=NO.O=S(=O)(O)O

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Hydroxyguanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BLM P54132 4/20 0.67
KDM4E B2RXH2 2/20 0.67
CA5A P35218 2/20 0.46
CA5B Q9Y2D0 2/20 0.46
TSHR P16473 3/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
NT5E P21589 1/20 0.40
CA4 P22748 1/20 0.40
CA6 P23280 1/20 0.40
CA7 P43166 1/20 0.40
CA9 Q16790 1/20 0.40
MEN1 O00255 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
MAPT P10636 1/20 0.40
AOC1 P19801 1/20 0.40
NFKB1 P19838 1/20 0.40
NOS3 P29474 1/20 0.40
NOS1 P29475 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydroxyguanidine SCHEMBL20520386 1.00 BLM (0.67) BLMKDM4ECA5ACA5BTSHR
Hydroxyguanidine SCHEMBL3574406 0.96 BLM (0.62) BLMKDM4ECA5ACA5BTSHR
Hydroxyguanidine SCHEMBL8874244 0.96 BLM (0.62) BLMKDM4ECA5ACA5BTSHR
Pimagedine SCHEMBL5968075 0.80 BLM (1.00) BLMKDM4ECA5ACA5BTSHR
Pimagedine SCHEMBL439904 0.80 BLM (1.00) BLMKDM4ECA5ACA5BTSHR
Hydroxyguanidine SCHEMBL116225 0.78
Pimagedine SCHEMBL28939704 0.77 BLM (0.92) BLMKDM4ECA5ACA5BTSHR
Sulfuric Acid SCHEMBL5581558 0.74 BLM (0.62) BLMKDM4ECA5ACA5BTSHR
Sulfuric Acid SCHEMBL7933433 0.73
Sulfuric Acid SCHEMBL145458 0.70 CA5A (0.60) BLMKDM4ECA5ACA5BTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025230907-A1 A CXCR4 ANTAGONIST, A STATS ACTIVATOR, AND/OR AN AGENT THAT INCREASES NITRIC OXIDE CONTENT FOR USE IN METHODS OF IMPROVING NERVE REGENERATION THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-11-06 WO claimed
EP-4426274-A1 NITRIC OXIDE DONORS FOR USE IN SURGICAL RECOVERY Baxter International Inc. (US) 2024-09-11 EP claimed
US-20240285831-A1 METHODS OF USE OF MODULATORS TO IMPROVE NERVE REGENERATION KEEFER, Edward (US) 2024-08-29 US claimed
US-11969522-B2 Use of immune modulators to improve nerve regeneration THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-04-30 US claimed
WO-2023081681-A1 NITRIC OXIDE DONORS FOR USE IN SURGICAL RECOVERY BAXTER INTERNATIONAL INC. (US) 2023-05-11 WO claimed
US-20230140515-A1 NITRIC OXIDE DONORS FOR USE IN SURGICAL RECOVERY BAXTER INTERNATIONAL INC. 2023-05-04 US claimed
CN-113698322-B Continuous production process method of hydroxyguanidine sulfate 大连理工大学 2022-11-04 CN claimed
CN-113698322-A Continuous production process method of hydroxyguanidine sulfate 大连理工大学 2021-11-26 CN claimed
CN-103751943-A Fire extinguishing composition containing nitrogenous organic compound XI AN JIAN RUI SAFETY EMERGENCY EQUIPMENT LTD LIABILITY COMPANY 2014-04-30 CN claimed
US-20090203050-A1 MOLECULAR SIGNALING PATHWAYS TRIGGERED BY RITUXIMAB: PROGNOSTIC, DIAGNOSTIC, AND THERAPEUTIC USES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-08-13 US claimed
US-20080311039-A1 Therapeutic and Prognostic Factor Yy1 in Human Cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-12-18 US claimed
US-20070172847-A1 MOLECULAR SIGNALING PATHWAYS TRIGGERED BY RITUXIMAB: PROGNOSTIC, DIAGNOSTIC, AND THERAPEUTIC USES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-07-26 US claimed
WO-2007011372-A2 THERAPEUTIC AND PROGNOSTIC FACTOR YY1 IN HUMAN CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-01-25 WO claimed
WO-2025230907-A1 A CXCR4 ANTAGONIST, A STATS ACTIVATOR, AND/OR AN AGENT THAT INCREASES NITRIC OXIDE CONTENT FOR USE IN METHODS OF IMPROVING NERVE REGENERATION THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-11-06 WO disclosed
US-20250186537-A1 TREATMENT OF WOMEN AFFECTED WITH POLYCYSTIC OVARY SYNDROME INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2025-06-12 US disclosed
US-12208130-B2 Treatment of women affected with polycystic ovary syndrome INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2025-01-28 US disclosed
EP-0239309-A2 Oxadiazoles useful in the treatment of senile dementia MERCK SHARP & DOHME LTD. (GB) 1987-09-30 EP disclosed
EP-0118543-A1 SUBSTITUTED N-BENZENESULFONYLOXYPHTHALIMIDES UNIVERSITY OF SOUTHERN CALIFORNIA (US) 1984-09-19 EP disclosed
US-4446142-A HYPOTENSIVE AGENTS BEIERSDORF AKTIENGESELLSCHAFT (DE) 1984-05-01 US disclosed
WO-1984000888-A1 SUBSTITUTED N-BENZENESULFONYLOXYPHTHALIMIDES UNIV SOUTHERN CALIFORNIA (US) 1984-03-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240285831-A1 METHODS OF USE OF MODULATORS TO IMPROVE NERVE REGENERATION CXCR3, CXCL12, CXCR4 BLM 2727/4885KDM4E 3304/4885CA5A 1820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.