Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 6/20 | 0.48 |
| ▸ | CTSS | P25774 | 5/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 5/20 | 0.47 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13258281 | 0.82 | ATM (0.50) | CTSKCTSSCTSLCTSBPPARA | |
| SCHEMBL13257955 | 0.82 | ATM (0.50) | CTSKCTSSCTSLCTSBPPARA | |
| SCHEMBL13257888 | 0.82 | ATM (0.50) | CTSKCTSSCTSLCTSBPPARA | |
| SCHEMBL203084 | 0.82 | ATM (0.67) | KLK5CTSKCTSSCTSLCTSB | |
| SCHEMBL29901268 | 0.82 | ATM (0.67) | KLK5CTSKCTSSCTSLCTSB | |
| SCHEMBL9977267 | 0.82 | ATM (0.67) | KLK5CTSKCTSSCTSLCTSB | |
| SCHEMBL3866896 | 0.82 | PPARA (0.49) | KLK5CTSKCTSSCTSLCTSB | |
| SCHEMBL6292728 | 0.81 | KLK5 (0.72) | KLK5CTSKCTSSCTSLCTSB | |
| SCHEMBL21473748 | 0.81 | KLK5 (0.72) | KLK5CTSKCTSSCTSLCTSB | |
| SCHEMBL84524 | 0.81 | KLK5 (0.72) | KLK5CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233483-B1 | Indole or Benzimidazole derivatives as IkB-kinase modulators and intermediates in their preparation. | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-05-09 | — | — | EP | disclosed |