Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 8/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 4/20 | 0.39 |
| ▸ | CDK4 | P11802 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18929761 | 0.83 | CA1 (0.46) | POLBTP53MAPT | |
| SCHEMBL4397150 | 0.80 | POLB (0.91) | POLBTP53MAPTSMN1; SMN2CTSD | |
| SCHEMBL6828696 | 0.80 | TP53 (0.67) | POLBTP53MAPTSMN1; SMN2 | |
| SCHEMBL14584575 | 0.79 | POLB (0.70) | POLBTP53MAPTSMN1; SMN2CTSD | |
| SCHEMBL1787817 | 0.75 | POLB (0.56) | POLBTP53MAPTSMN1; SMN2SLC9A3 | |
| SCHEMBL2187675 | 0.75 | POLB (0.60) | POLBTP53MAPTSMN1; SMN2SLC9A3 | |
| SCHEMBL4833669 | 0.74 | TP53 (0.64) | POLBTP53MAPTSMN1; SMN2 | |
| SCHEMBL13745531 | 0.72 | POLB (0.56) | POLBTP53MAPTSMN1; SMN2SLC9A3 | |
| SCHEMBL12547064 | 0.72 | POLB (0.56) | POLBTP53MAPTSMN1; SMN2SLC9A3 | |
| SCHEMBL10192187 | 0.72 | TP53 (0.64) | POLBTP53MAPTSMN1; SMN2SLC9A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959951-B1 | HETEROARYL SUBSTITUTED PIPERIDINE DERIVATIVES AS L-CPT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-12-23 | — | — | EP | disclosed |