Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 9/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1583553 | 0.87 | TP53 (0.52) | TP53POLBSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14584575 | 0.86 | POLB (0.70) | TP53POLBSMN1; SMN2MAPTGAA | |
| SCHEMBL4833669 | 0.85 | TP53 (0.64) | TP53POLBSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5434812 | 0.84 | ALDH1A1 (0.60) | TP53POLBSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL4397150 | 0.84 | POLB (0.91) | TP53POLBSMN1; SMN2MAPTGAA | |
| SCHEMBL475737 | 0.83 | POLB (0.55) | TP53POLBSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL18767065 | 0.82 | POLB (0.54) | TP53POLBSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5901042 | 0.82 | TP53 (0.48) | TP53POLBSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5225022 | 0.81 | TP53 (0.47) | TP53POLBSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5222204 | 0.81 | TP53 (0.47) | TP53POLBSMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111022-A1 | 3-(1,1-DIOXOTETRAHYDRO-1,2-THIAZIN-2-YL) or 3-(1,1-DOXO-ISOTHIAZOLIDIN-2YL) SUBSTITUTED BENZAMIDE COMPOUNDS AS ASP2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |