Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.91 |
| ▸ | TP53 | P04637 | 8/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14584575 | 0.87 | POLB (0.70) | POLBTP53ALDH1A1HPGDKDM4E | |
| SCHEMBL4831916 | 0.85 | POLB (0.68) | POLBTP53ALDH1A1HPGDKDM4E | |
| SCHEMBL6828696 | 0.84 | TP53 (0.67) | POLBTP53ALDH1A1HPGDGAA | |
| SCHEMBL4833669 | 0.81 | TP53 (0.64) | POLBTP53ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1937229 | 0.81 | POLB (0.61) | POLBTP53ALDH1A1HPGDKDM4E | |
| SCHEMBL4401152 | 0.80 | POLB (0.61) | POLBTP53MAPTSMN1; SMN2CTSD | |
| SCHEMBL5900600 | 0.79 | POLB (0.59) | POLBTP53MAPTSMN1; SMN2 | |
| SCHEMBL14584576 | 0.78 | POLB (0.58) | POLBTP53ALDH1A1HPGDGAA | |
| SCHEMBL1787817 | 0.76 | POLB (0.56) | POLBTP53MAPTSMN1; SMN2 | |
| SCHEMBL12547064 | 0.76 | POLB (0.56) | POLBTP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11458124-B2 | Spirocyclic indane analogues as IL-17 modulators | UCBBiopharma Srl (BE) | 2022-10-04 | — | — | US | disclosed |
| US-20210228547-A1 | Spirocyclic Indane Analogues as IL-17 Modulators | UCB BIOPHARMA SRL (SOCIETE A RESPONSABILITE LIMITEE) (BE) | 2021-07-29 | — | — | US | disclosed |
| EP-3820567-A1 | SPIROCYCLIC INDANE ANALOGUES AS IL-17 MODULATORS | UCB Biopharma SRL (BE) | 2021-05-19 | — | — | EP | disclosed |
| CN-112334192-A | Spirocyclic indane analogs as IL-17 modulators | UCB生物制药有限责任公司 | 2021-02-05 | — | — | CN | disclosed |
| WO-2020011731-A1 | SPIROCYCLIC INDANE ANALOGUES AS IL-17 MODULATORS | UCB Biopharma SRL (BE) | 2020-01-16 | — | — | WO | disclosed |
| EP-1959951-B1 | HETEROARYL SUBSTITUTED PIPERIDINE DERIVATIVES AS L-CPT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-12-23 | — | — | EP | disclosed |
| US-7442704-B2 | Amide derivatives | ASTRAZENECA AB (SE) | 2008-10-28 | — | — | US | disclosed |
| US-7332483-B2 | 3-(5-benzamido-2-chlorophenyl)-7-methoxy-3,4-dihydroquinazolin-4-one;cytokines (tumor necrosis factor and interleukins) inhibitor; antiinflammatory agent, rheumatoid arthritis, osteoarthritis, psoriasis, chronic obstructive pulmonary disease | ASTRAZENECA AB (SE) | 2008-02-19 | — | — | US | disclosed |
| US-20060281734-A1 | Amide derivatives | BROWN DEARG S | 2006-12-14 | — | — | US | disclosed |
| US-7008945-B1 | Amide derivatives | ASTRAZENECA AB (SE) | 2006-03-07 | — | — | US | disclosed |
| US-20050245551-A1 | Amide derivatives | ASTRAZENECA AB | 2005-11-03 | — | — | US | disclosed |
| WO-2005030709-A1 | NOVEL SULFONE AMIDE DERIVATIVES CAPABLE OF INHIBITING BACE | LG LIFE SCIENCES LTD. (KR) | 2005-04-07 | — | — | WO | disclosed |
| WO-2004111022-A1 | 3-(1,1-DIOXOTETRAHYDRO-1,2-THIAZIN-2-YL) or 3-(1,1-DOXO-ISOTHIAZOLIDIN-2YL) SUBSTITUTED BENZAMIDE COMPOUNDS AS ASP2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |
| EP-1163237-A1 | AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055153-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210228547-A1 | Spirocyclic Indane Analogues as IL-17 Modulators | IL17A, IL18, IL23R | POLB 3767/4885TP53 2999/4885ALDH1A1 195/4885 |
| US-20050245551-A1 | Amide derivatives | IL6, IL6ST, IL1B | POLB 3576/4885TP53 2400/4885ALDH1A1 269/4885 |
| US-20060281734-A1 | Amide derivatives | IL6, IL6ST, IL1B | POLB 3576/4885TP53 2400/4885ALDH1A1 269/4885 |
| US-11458124-B2 | Spirocyclic indane analogues as IL-17 modulators | IL17A, IL18, IL23R | POLB 3767/4885TP53 2999/4885ALDH1A1 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.