Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761656 | 0.87 | RAB9A (0.56) | RAB9APOLBNPC1TP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1761614 | 0.86 | RAB9A (0.55) | RAB9APOLBNPC1TP53SMN1; SMN2 | |
| SCHEMBL4410950 | 0.85 | RAB9A (0.54) | RAB9APOLBNPC1TP53SMN1; SMN2 | |
| SCHEMBL14260982 | 0.85 | RAB9A (0.54) | RAB9APOLBNPC1TP53SMN1; SMN2 | |
| SCHEMBL28094973 | 0.83 | RAB9A (0.52) | RAB9APOLB | |
| SCHEMBL6084174 | 0.73 | RAB9A (0.78) | RAB9APOLBNPC1TP53SMN1; SMN2 | |
| SCHEMBL6084166 | 0.73 | RAB9A (0.78) | RAB9APOLBNPC1TP53SMN1; SMN2 | |
| SCHEMBL28891069 | 0.73 | NPC1 (0.68) | RAB9AMEN1KMT2ANPC1TP53 | |
| SCHEMBL5592854 | 0.73 | TP53 (0.69) | RAB9AMEN1KMT2ANPC1TP53 | |
| SCHEMBL13485789 | 0.73 | NPC1 (0.68) | RAB9AMEN1KMT2ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796657-B1 | N-2 ADAMANTANYL-2-PHENOXY-ACETAMIDE DERIVATIVES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-23 | — | — | EP | claimed |