Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963729 | 0.87 | KMT2A (0.42) | LMNAPARP1PARP2IDH1KDM4E | |
| SCHEMBL4402091 | 0.87 | LMNA (0.42) | LMNAPARP1ADRB3HTR1AABCB11 | |
| SCHEMBL4551166 | 0.87 | LMNA (0.42) | LMNAPARP1ADRB3HTR1AABCB11 | |
| SCHEMBL4405829 | 0.86 | PARP1 (0.37) | LMNAPARP1ADRB3HTR1AABCB11 | |
| SCHEMBL4406787 | 0.86 | PARP1 (0.37) | LMNAPARP1ADRB3HTR1AABCB11 | |
| SCHEMBL4409085 | 0.86 | LMNA (0.40) | LMNAPARP1ADRB3HTR1AABCB11 | |
| SCHEMBL4405571 | 0.85 | KDM4E (0.39) | LMNAPARP1ADRB3HTR1AKDM4E | |
| SCHEMBL4396585 | 0.85 | LMNA (0.40) | LMNAPARP1ADRB3HTR1AABCB11 | |
| SCHEMBL4406828 | 0.85 | PARP1 (0.37) | LMNAPARP1ADRB3HTR1AABCB11 | |
| Hydrochloric Acid SCHEMBL4405691 | 0.84 | LMNA (0.37) | LMNAHTR1AABCB11ADRA2APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |