Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.66 |
| ▸ | HTT | P42858 | 6/20 | 0.66 |
| ▸ | LMNA | P02545 | 5/20 | 0.66 |
| ▸ | NAMPT | P43490 | 4/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | GALR3 | O60755 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27083360 | 0.91 | SMN1; SMN2 (0.73) | SMN1; SMN2HTTLMNANAMPTRAB9A | |
| SCHEMBL4402165 | 0.87 | SMN1; SMN2 (0.65) | SMN1; SMN2HTTLMNANAMPTCYP19A1 | |
| SCHEMBL27083363 | 0.86 | SMN1; SMN2 (0.82) | SMN1; SMN2HTTLMNANAMPTRAB9A | |
| SCHEMBL4894460 | 0.82 | LMNA (0.65) | SMN1; SMN2HTTLMNANAMPTKMT2A | |
| SCHEMBL4891523 | 0.81 | CYP19A1 (0.73) | SMN1; SMN2HTTLMNANAMPTCYP19A1 | |
| SCHEMBL27083341 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2HTTLMNANAMPTRAB9A | |
| SCHEMBL4402169 | 0.80 | MEN1 (0.49) | SMN1; SMN2HTTLMNANAMPTCYP19A1 | |
| SCHEMBL30864994 | 0.80 | LMNA (0.58) | SMN1; SMN2HTTLMNANAMPTKMT2A | |
| SCHEMBL27083331 | 0.80 | LMNA (0.58) | SMN1; SMN2HTTLMNANAMPTCYP19A1 | |
| SCHEMBL27083343 | 0.80 | LMNA (0.58) | SMN1; SMN2HTTLMNANAMPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178540-B2 | Pyrimidylmethyl-sulfonamide compounds | BASF SE (DE) | 2012-05-15 | — | — | US | disclosed |
| US-8178540-B2 | Pyrimidylmethyl-sulfonamide compounds | BASF SE (DE) | 2012-05-15 | — | — | US | disclosed |
| US-20100069243-A1 | Pyrimidylmethyl-Sulfonamide Compounds | BASF SE (DE) | 2010-03-18 | — | — | US | disclosed |
| US-20100069243-A1 | Pyrimidylmethyl-Sulfonamide Compounds | BASF SE (DE) | 2010-03-18 | — | — | US | disclosed |
| WO-2008062011-A1 | PYRIMIDYLMETHYL-SULFONAMIDE COMPOUNDS USEFUL AS FUNGICIDES AND AGAINST ARTHROPODS | BASF SE (DE) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069243-A1 | Pyrimidylmethyl-Sulfonamide Compounds | TPMT, NISCH, PPA1 | SMN1; SMN2 768/4885HTT 2587/4885LMNA 4514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.