SCHEMBL4894460

SCHEMBL4894460

O=S(=O)(NCc1ccncc1)c1ccc(-c2ccccc2Cl)cc1

nearest known ligand 0.65

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.65
SMN1; SMN2 Q16637 5/20 0.65
HTT P42858 4/20 0.58
RAB9A P51151 5/20 0.54
KMT2A Q03164 1/20 0.53
NR2F2 P24468 2/20 0.52
ALDH1A1 P00352 2/20 0.52
NAMPT P43490 5/20 0.52
NPC1 O15118 2/20 0.52
GALR3 O60755 1/20 0.52
SLC12A2 P55011 1/20 0.49
SLC12A5 Q9H2X9 1/20 0.49
KEAP1 Q14145 1/20 0.49
CYP1A2 P05177 1/20 0.48
POLB P06746 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
MAPT P10636 1/20 0.48
CYP2C19 P33261 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27083363 0.83 SMN1; SMN2 (0.82) LMNASMN1; SMN2HTTRAB9ANR2F2
SCHEMBL30864994 0.82 LMNA (0.58) LMNASMN1; SMN2HTTRAB9AKMT2A
SCHEMBL27083343 0.82 LMNA (0.58) LMNASMN1; SMN2HTTRAB9AKMT2A
SCHEMBL4402015 0.82 SMN1; SMN2 (0.66) LMNASMN1; SMN2HTTRAB9AKMT2A
SCHEMBL27083360 0.81 SMN1; SMN2 (0.73) LMNASMN1; SMN2HTTRAB9ANR2F2
SCHEMBL4662893 0.80 SMN1; SMN2 (1.00) LMNASMN1; SMN2HTTRAB9ANR2F2
SCHEMBL27083331 0.77 LMNA (0.58) LMNASMN1; SMN2HTTRAB9AKMT2A
SCHEMBL30865004 0.76 SMN1; SMN2 (0.66) LMNASMN1; SMN2HTTRAB9ANR2F2
SCHEMBL27083380 0.76 SMN1; SMN2 (0.66) LMNASMN1; SMN2HTTRAB9ANR2F2
SCHEMBL27083341 0.76 SMN1; SMN2 (0.64) LMNASMN1; SMN2HTTRAB9ANR2F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1860941-B1 BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES BASF SE (DE) 2008-11-12 EP disclosed
US-20080161187-A1 Controlling phytopathogenic harmful fungi and harmful arthropodes; combating arthropodal pestsprotecting crops, seeds and non-living materials from infestation by arthropodal pests; insecticides, pesticides, fungicides; miticides; agriculture; veterinary medicine BASF AKTIENGESELLSCHAFT (DE) 2008-07-03 US disclosed
EP-1860941-A1 BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES BASF AKTIENGESELLSCHAFT (DE) 2007-12-05 EP disclosed
WO-2006097489-A1 BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES BASF AKTIENGESELLSCHAFT (DE) 2006-09-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161187-A1 Controlling phytopathogenic harmful fungi and harmful arthropodes; combating arthropodal pestsprotecting crops, seeds and non-living materials from infestation by arthropodal pests; insecticides, pesticides, fungicides; miticides; agriculture; veterinary medicine PTPN21, PTPN1, PTPN14 LMNA 4054/4885SMN1; SMN2 2697/4885HTT 783/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.