Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 6/20 | 0.51 |
| ▸ | ITGB7 | P26010 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL980626 | 0.99 | ITGA4 (0.50) | ITGA4ITGB7MEN1CRHBPKMT2A | |
| Hydrochloric Acid SCHEMBL27872090 | 0.99 | ITGA4 (0.50) | ITGA4ITGB7MEN1CRHBPKMT2A | |
| SCHEMBL15846974 | 0.82 | HSD17B10 (0.49) | MEN1CRHBPKMT2ACRHR2ALDH1A1 | |
| Bromide SCHEMBL17203097 | 0.82 | MAPT (0.44) | ITGA4ITGB7MEN1KMT2AALDH1A1 | |
| SCHEMBL15848192 | 0.82 | ALDH1A1 (0.49) | MEN1CRHBPKMT2ACRHR2ALDH1A1 | |
| Bromide SCHEMBL5828152 | 0.81 | HSD17B10 (0.47) | MEN1CRHBPKMT2ACRHR2ALDH1A1 | |
| Bromide SCHEMBL2468888 | 0.81 | ALDH1A1 (0.45) | ITGA4ITGB7MEN1KMT2AALDH1A1 | |
| SCHEMBL8409393 | 0.79 | ITGA4 (0.53) | ITGA4ITGB7MEN1CRHBPKMT2A | |
| Bromide SCHEMBL5829133 | 0.78 | POLB (0.45) | MEN1KMT2AALDH1A1TSHRTDP1 | |
| Bromide SCHEMBL5828146 | 0.78 | HSD17B10 (0.47) | MEN1CRHBPKMT2ACRHR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130046103-A1 | PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES | MAPI PHARMA LIMITED (IL) | 2013-02-21 | — | — | US | disclosed |
| US-20120108828-A1 | SYNTHESIS OF DRONEDARONE AND SALTS THEREOF | USV Limited, B.S.D. Marg (IN) | 2012-05-03 | — | — | US | disclosed |
| US-7312345-B2 | Process for the preparation of dronedarone | ISP INVESTMENTS INC. (US) | 2007-12-25 | — | — | US | disclosed |
| EP-0859776-A1 | COMPOUNDS DERIVED FROM OXAZOLIDIN-2-ONE AND PREPARATION AND THERAPEUTICAL USE THEREOF | SYNTHELABO (FR) | 1998-08-26 | — | — | EP | disclosed |
| EP-0859775-A1 | COMPOUNDS DERIVED FROM 3-(BENZOFURAN-5-YL)OXAZOLIDIN-2-ONE, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF | SYNTHELABO (FR) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997017346-A1 | COMPOUNDS DERIVED FROM 3-(BENZOFURAN-5-YL)OXAZOLIDIN-2-ONE, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF | SYNTHELABO (FR) | 1997-05-15 | — | — | WO | disclosed |
| WO-1997017347-A1 | COMPOUNDS DERIVED FROM OXAZOLIDIN-2-ONE AND PREPARATION AND THERAPEUTICAL USE THEREOF | SYNTHELABO (FR) | 1997-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108828-A1 | SYNTHESIS OF DRONEDARONE AND SALTS THEREOF | CYP3A4, CYP2D6, CYP3A43 | ITGA4 3352/4885ITGB7 4226/4885MEN1 2739/4885 |
| US-20130046103-A1 | PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES | CYP2F1, CYP4F3, CYP2D6 | ITGA4 3763/4885ITGB7 3117/4885MEN1 2178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.