Pyrazole

Pyrazole

SCHEMBL440249

NC(=O)O.c1cn[nH]c1

nearest known ligand 0.00

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⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrazole SCHEMBL1129000 0.92
Oxamate SCHEMBL30882809 0.91 LDHA (0.41)
Pyrazole SCHEMBL28727019 0.90
Pyrazole SCHEMBL20495491 0.90
Pyrazole SCHEMBL5064075 0.90 HCAR2 (0.31)
Pyrazole SCHEMBL28095827 0.88
Pyrazole SCHEMBL6009803 0.88
Oxalic Acid SCHEMBL27899728 0.87 HCAR2 (0.30)
Oxalic Acid SCHEMBL27705066 0.87 HCAR2 (0.30)
Pyrazole SCHEMBL27529556 0.86 FFAR3 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108366565-A Novel plant protection compositions and their use 弗莱克西格专利有限责任公司 2018-08-03 CN claimed
CN-101585811-B Pyrazole carbamate genus compound containing alkynes aryl as well as preparation method and application thereof UNIV SOUTH CHINA AGRICULT 2012-01-04 CN claimed
CN-101585811-A Pyrazole carbamate genus compound containing alkynes aryl as well as preparation method and application thereof UNIV SOUTH CHINA AGRICULT (CN) 2009-11-25 CN claimed
EP-1881964-A1 PYRAZOLOCARBOXAMIDES AS FUNGICIDES BASF AKTIENGESELLSCHAFT (DE) 2008-01-30 EP claimed
WO-2006120219-A1 PYRAZOLOCARBOXAMIDES AS FUNGICIDES BASF AKTIENGESELLSCHAFT (DE) 2006-11-16 WO claimed
EP-1148879-A2 USE OF PYRAZOLE CARBOXAMIDES Bayer Aktiengesellschaft (DE) 2001-10-31 EP claimed
WO-2000045894-A2 USE OF PYRAZOLE CARBOXAMIDES BAYER AKTIENGESELLSCHAFT (DE) 2000-08-10 WO claimed
EP-0419917-A1 Pyrazol-3-carboxylic acid amides BASF Aktiengesellschaft (DE) 1991-04-03 EP claimed
US-20250171405-A1 PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS BIOHAVEN THERAPEUTICS LTD (US) 2025-05-29 US disclosed
US-12209072-B2 Cyclopentyl acids as LPA antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 2025-01-28 US disclosed
EP-4482487-A1 PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS Biohaven Therapeutics Ltd. (US) 2025-01-01 EP disclosed
CN-112041302-B Pyrazole O-linked carbamoyl cyclohexyl acids as LPA antagonists 百时美施贵宝公司 2024-11-19 CN disclosed
US-11980609-B2 LPA receptor antagonists and uses thereof GILEAD SCIENCES, INC. (US) 2024-05-14 US disclosed
EP-4337641-A1 LPA RECEPTOR ANTAGONISTS AND USES THEREOF GILEAD SCIENCES, INC. (US) 2024-03-20 EP disclosed
WO-2000045894-A3 USE OF PYRAZOLE CARBOXAMIDES BAYER AG (DE) 2001-04-19 WO disclosed
WO-2000045894-A2 USE OF PYRAZOLE CARBOXAMIDES BAYER AKTIENGESELLSCHAFT (DE) 2000-08-10 WO disclosed
WO-2000045894-A2 USE OF PYRAZOLE CARBOXAMIDES BAYER AKTIENGESELLSCHAFT (DE) 2000-08-10 WO disclosed
EP-0882022-A1 ASPARTYL PROTEASE INHIBITORS Vertex Pharmaceuticals Incorporated (US) 1998-12-09 EP disclosed
WO-1997027180-A1 ASPARTYL PROTEASE INHIBITORS VERTEX PHARMACEUTICALS INCORPORATED (US) 1997-07-31 WO disclosed
EP-0590720-A1 Pyrazolecarboxamides exhibiting insecticidal and acaricidal activity MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA (IT) 1994-04-06 EP disclosed