Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | NEK2 | P51955 | 1/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | STK3 | Q13188 | 1/20 | 0.51 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.51 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.51 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.51 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6214929 | 0.86 | PLK1 (0.68) | PLK1CYP2C9PLK3MAP4K4CSF1R | |
| SCHEMBL3569955 | 0.83 | PLK1 (0.84) | PLK1CYP2C9PLK3CYP3A4 | |
| SCHEMBL6214432 | 0.82 | PLK1 (0.84) | PLK1PLK3MAP4K4CSF1RKDR | |
| SCHEMBL5002950 | 0.80 | PLK1 (0.61) | PLK1CYP2C9PLK3CYP3A4MAP4K4 | |
| SCHEMBL4404992 | 0.77 | PLK1 (0.78) | PLK1CYP2C9PLK3CYP3A4CSF1R | |
| SCHEMBL5008546 | 0.76 | PLK1 (0.63) | PLK1CYP2C9PLK3CYP3A4 | |
| SCHEMBL3156658 | 0.75 | PLK1 (0.86) | PLK1CYP2C9PLK3CYP3A4 | |
| SCHEMBL4726481 | 0.75 | PLK1 (0.86) | PLK1CYP2C9PLK3CYP3A4 | |
| SCHEMBL4413428 | 0.75 | PLK1 (0.87) | PLK1CYP2C9PLK3CYP3A4 | |
| SCHEMBL3151246 | 0.74 | PLK1 (0.80) | PLK1CYP2C9PLK3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-B1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORP (US) | 2009-12-30 | — | — | EP | disclosed |