Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.68 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | NEK2 | P51955 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | STK3 | Q13188 | 1/20 | 0.54 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.54 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.54 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.54 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6214432 | 0.87 | PLK1 (0.84) | PLK1PLK3MAP4K4CSF1RKDR | |
| SCHEMBL4402863 | 0.86 | PLK1 (0.61) | PLK1PLK3MAP4K4CSF1RPIM1 | |
| SCHEMBL6210332 | 0.83 | PLK1 (0.56) | PLK1PLK3NEK2 | |
| SCHEMBL5067368 | 0.80 | PLK1 (0.78) | PLK1PLK3PIM1KDRNEK2 | |
| SCHEMBL5008546 | 0.77 | PLK1 (0.63) | PLK1PLK3CYP2C9 | |
| SCHEMBL4404992 | 0.77 | PLK1 (0.78) | PLK1PLK3CSF1RCYP2C9 | |
| SCHEMBL5058244 | 0.76 | PLK1 (1.00) | PLK1PLK3MAP4K4CSF1RPIM1 | |
| SCHEMBL4406267 | 0.76 | PLK1 (0.55) | PLK1PLK3PIM1KDRNEK2 | |
| Trifluoroacetic Acid SCHEMBL4408558 | 0.76 | PLK1 (0.54) | PLK1PLK3MAP4K4CSF1RPIM1 | |
| SCHEMBL3732113 | 0.75 | PLK1 (0.58) | PLK1PLK3MAP4K4CSF1RKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546137-A1 | BENZIMIDAZOL-1-YL-THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER | SmithKline Beecham Corporation (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004014899-A1 | THIOPHENE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-19 | — | — | WO | disclosed |