Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Asparagine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | GLI1 | P08151 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.32 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asparagine SCHEMBL4607285 | 1.00 | NOS2 (0.37) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL4995025 | 0.95 | NOS2 (0.33) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL28252029 | 0.94 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL2537700 | 0.94 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL27708267 | 0.94 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL2484608 | 0.94 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL2484607 | 0.94 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL2537696 | 0.94 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL28801809 | 0.94 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Leucine SCHEMBL4397081 | 0.93 | SLC7A5 (0.43) | NOS2NOS3NOS1GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560430-B2 | To stimulate the endogenous production of Elastin or appear to enhance the elasticity of the skin | HUMAN MATRIX SCIENCES, LLC (US) | 2009-07-14 | — | — | US | disclosed |