Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4402972 | 0.89 | MEN1 (0.45) | MEN1KMT2AKDM4EACACBACACA | |
| SCHEMBL2671776 | 0.84 | MAP2K4 (0.50) | LRRK2KDM4EACACBACACARAB9A | |
| SCHEMBL30189210 | 0.84 | MAP2K4 (0.50) | LRRK2KDM4EACACBACACARAB9A | |
| SCHEMBL29301471 | 0.82 | KDM4E (0.50) | MEN1KMT2ALRRK2KDM4ENPC1 | |
| SCHEMBL4403122 | 0.81 | MAPK1 (0.43) | PAK1KDM4ENPC1RAB9AMAPT | |
| SCHEMBL10242014 | 0.80 | ACACB (0.44) | LRRK2KDM4EACACBACACANPC1 | |
| SCHEMBL30147526 | 0.80 | CCNC (0.50) | LRRK2CYP1A2 | |
| SCHEMBL10282868 | 0.77 | PAK1 (0.49) | PAK1KDM4EACACBACACANPC1 | |
| SCHEMBL4403022 | 0.77 | CDK8 (0.47) | PAK1ACACBACACAPRKAA1MAPK1 | |
| SCHEMBL2056319 | 0.74 | CNR2 (0.45) | LRRK2NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012056372-A1 | N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-05-03 | — | — | WO | disclosed |