Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 5/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4402091 | 0.92 | LMNA (0.42) | PARP1LMNAHTR7HTR1ACCR8 | |
| SCHEMBL4551166 | 0.92 | LMNA (0.42) | PARP1LMNAHTR7HTR1ACCR8 | |
| SCHEMBL4405829 | 0.89 | PARP1 (0.37) | PARP1LMNAHTR7HTR1ACCR8 | |
| SCHEMBL4406787 | 0.89 | PARP1 (0.37) | PARP1LMNAHTR7HTR1ACCR8 | |
| SCHEMBL4406828 | 0.89 | PARP1 (0.37) | PARP1LMNAHTR7HTR1AADRB3 | |
| SCHEMBL914120 | 0.88 | PARP1 (0.42) | PARP1LMNAHTR7HTR1AHTR4 | |
| SCHEMBL4409085 | 0.88 | LMNA (0.40) | PARP1LMNAHTR7HTR1AADRB3 | |
| SCHEMBL4405571 | 0.87 | KDM4E (0.39) | PARP1LMNAHTR7HTR1AADRB3 | |
| SCHEMBL4396585 | 0.87 | LMNA (0.40) | PARP1LMNAHTR7HTR1AADRB3 | |
| SCHEMBL4406705 | 0.84 | LMNA (0.38) | PARP1LMNAHTR7HTR1AADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |