Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 11/20 | 0.77 |
| ▸ | NPC1 | O15118 | 3/20 | 0.77 |
| ▸ | MAPT | P10636 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.77 |
| ▸ | RAB9A | P51151 | 3/20 | 0.77 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.77 |
| ▸ | IKBKB | O14920 | 1/20 | 0.77 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.77 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.77 |
| ▸ | PRKCG | P05129 | 1/20 | 0.77 |
| ▸ | CDK1 | P06493 | 1/20 | 0.77 |
| ▸ | LYN | P07948 | 1/20 | 0.77 |
| ▸ | KIT | P10721 | 1/20 | 0.77 |
| ▸ | PIM1 | P11309 | 1/20 | 0.77 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.77 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.77 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.77 |
| ▸ | CDK2 | P24941 | 1/20 | 0.77 |
| ▸ | MARK3 | P27448 | 1/20 | 0.77 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440486 | 0.87 | AURKA (1.00) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL7775625 | 0.86 | AURKA (0.77) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL10065608 | 0.78 | CYP1A2 (0.47) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL5384269 | 0.78 | AURKA (0.87) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL31046509 | 0.78 | AURKA (0.81) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL4621303 | 0.78 | NPC1 (0.87) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL4624975 | 0.78 | NPC1 (0.65) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL857880 | 0.78 | AURKA (0.70) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL29695677 | 0.78 | AURKA (0.64) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL582624 | 0.78 | EPHB4 (0.58) | AURKANPC1MAPTMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |