Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Enoximone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B known ✓ | Q13370 | 3/20 | 1.00 |
| ▸ | PDE3A known ✓ | Q14432 | 3/20 | 1.00 |
| ▸ | PDE4A | P27815 | 11/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 11/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 11/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 11/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enoximone SCHEMBL5153559 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Enoximone SCHEMBL5702415 | 0.94 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Enoximone SCHEMBL28068937 | 0.85 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7442148 | 0.83 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9787151 | 0.83 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5457930 | 0.81 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10635511 | 0.81 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7416132 | 0.80 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL11181578 | 0.80 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10924200 | 0.80 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5648 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| EP-4081242-B1 | TREATMENT OF ACUTE HEART FAILURE | AnaCardio R&D AB (SE) | 2025-09-10 | — | — | EP | claimed |
| EP-4561649-A1 | DRUG-COATED MEDICAL DEVICES AND METHODS OF MAKING | Bard Peripheral Vascular, Inc. (US) | 2025-06-04 | — | — | EP | claimed |
| CN-120018870-A | Drug coated medical device and method of manufacture | 巴德血管外围设备公司 | 2025-05-16 | — | — | CN | claimed |
| CN-119746100-A | Engineering long-acting platelet delivery system with therapeutic drug carried therein, and preparation method and application thereof | 沈阳药科大学 | 2025-04-04 | — | — | CN | claimed |
| WO-2025038398-A1 | METHODS OF PREVENTING OR TREATING LIVER DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2025-02-20 | — | — | WO | claimed |
| WO-2025023975-A1 | METHODS FOR THE PREPARATION OF PHOSPHOLIPID BILAYER CARRIERS | BARD PERIPHERAL VASCULAR, INC. (US) | 2025-01-30 | — | — | WO | claimed |
| CN-119303086-A | Pharmaceutical composition for treating autism | 斯塔利克拉股份有限公司 | 2025-01-14 | — | — | CN | claimed |
| WO-2024254056-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | CATALENT ONTARIO LIMITED (CA) | 2024-12-12 | — | — | WO | claimed |
| WO-2024242668-A1 | PROTECTIVE COVERINGS FOR DRUG COATED BALLOONS | BARD PERIPHERAL VASCULAR, INC. (US) | 2024-11-28 | — | — | WO | claimed |
| WO-1998058638-A1 | METHOD OF TREATING HEART FAILURE | BRISTOW MICHAEL R (US) | 1998-12-30 | — | — | WO | claimed |
| WO-1998010765-A1 | NON-HORMONAL METHOD OF CONTRACEPTION | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 1998-03-19 | — | — | WO | claimed |
| EP-0326103-B1 | PHARMACEUTICAL COMPOSITION FOR 4-AROYLIMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-15 | — | — | EP | claimed |
| EP-0169164-B1 | IMIDAZOLONECARBONYLARYLIMIDAZOLES; METHOD OF MANUFACTURE, METHOD OF USE AND COMPOSITIONS USEFUL THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-01-31 | — | — | EP | claimed |
| US-4868182-A | HYPOTENSIVE AND CARDIOTONIC, SYNERGISTIC | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-19 | — | — | US | claimed |
| EP-0326103-A1 | Pharmaceutical composition for 4-aroylimidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-08-02 | — | — | EP | claimed |
| EP-0268146-A1 | Enhancement of prazosin | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-05-25 | — | — | EP | claimed |
| US-4709043-A | Process for the preparation of imidazolonecarbonylarylimidazoles | SCHERING A.G. (DE) | 1987-11-24 | — | — | US | claimed |
| EP-0169164-A1 | Imidazolonecarbonylarylimidazoles; method of manufacture, method of use and compositions useful thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-01-22 | — | — | EP | claimed |
| US-4405635-A | HYPOTENSIVE, CARDIOTONIC, BRONCHODILATOR, ANTICOAGULANT, AND MUSCLE RELAXANT AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | claimed |