Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Enoximone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B known ✓ | Q13370 | 3/20 | 1.00 |
| ▸ | PDE3A known ✓ | Q14432 | 3/20 | 1.00 |
| ▸ | PDE4A | P27815 | 11/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 11/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 11/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 11/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enoximone SCHEMBL44049 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Enoximone SCHEMBL5702415 | 0.94 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Enoximone SCHEMBL28068937 | 0.85 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7442148 | 0.83 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9787151 | 0.83 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5457930 | 0.81 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10635511 | 0.81 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7416132 | 0.80 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL11181578 | 0.80 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10924200 | 0.80 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737447-A1 | (R)-ENOXIMONE SULFOXIDE AND ITS USE IN THE TREATMENT OF PDE-III MEDIATED DISEASES | MYOGEN, INC. (US) | 2007-01-03 | — | — | EP | disclosed |
| EP-1737448-A1 | (S) - ENOXIMONE SULFOXIDE AND ITS USE IN THE TREATMENT OF PDE-III MEDIATED DISEASES | MYOGEN, INC. (US) | 2007-01-03 | — | — | EP | disclosed |
| EP-1699436-A2 | ENOXIMONE FORMULATIONS AND THEIR USE IN THE TREATMENT OF CARDIAC HYPERTROPHY AND HEART FAILURE | MYOGEN, INC. (US) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005092332-A1 | (S) - ENOXIMONE SULFOXIDE AND ITS USE IN THE TREATMENT OF PDE-III MEDIATED DISEASES | MYOGEN, INC. (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2005092333-A1 | (R)-ENOXIMONE SULFOXIDE AND ITS USE IN THE TREATMENT OF PDE-III MEDIATED DISEASES | MYOGEN, INC. (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2005058280-A2 | ENOXIMONE FORMULATIONS AND THEIR USE IN THE TREATMENT OF CARDIAC HYPERTROPHY AND HEART FAILURE | MYOGEN, INC. (US) | 2005-06-30 | — | — | WO | disclosed |
| EP-1252158-A1 | NICOTINAMIDE BENZOFUSED-HETEROCYCLYL DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF PDE4 ISOZYMES | Pfizer Products Inc. (US) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057036-A1 | NICOTINAMIDE BENZOFUSED-HETEROCYCLYL DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF PDE4 ISOZYMES | PFIZER PRODUCTS INC. (US) | 2001-08-09 | — | — | WO | disclosed |