Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.70 |
| ▸ | TSHR | P16473 | 3/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.70 |
| ▸ | ATM | Q13315 | 1/20 | 0.70 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.70 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enoximone SCHEMBL44049 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTSHR | |
| Enoximone SCHEMBL5153559 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL9787264 | 0.82 | LMNA (0.47) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL9787252 | 0.81 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL9787361 | 0.81 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL9787097 | 0.81 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL7438756 | 0.80 | ALDH1A1 (0.45) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL7430668 | 0.78 | NPSR1 (0.47) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL9787057 | 0.78 | MAPT (0.55) | PDE4APDE4BPDE4CPDE4DTSHR | |
| Enoximone SCHEMBL5702415 | 0.78 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4868197-A | REDUCING INJURY CAUSED BY REINTRODUCTION OF OXYGEN TO HEART TISSUE AFTER ATTACK | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-19 | — | — | US | claimed |
| US-4999365-A | Preventing damage which occurs to heart tissue when oxygen is reintroduced after a heart attack | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-03-12 | — | — | US | disclosed |
| US-4868197-A | REDUCING INJURY CAUSED BY REINTRODUCTION OF OXYGEN TO HEART TISSUE AFTER ATTACK | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-19 | — | — | US | disclosed |
| US-4868197-A | REDUCING INJURY CAUSED BY REINTRODUCTION OF OXYGEN TO HEART TISSUE AFTER ATTACK | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-19 | — | — | US | disclosed |
| EP-0284925-A2 | Use of imidazol-2-thiones for the preparation of a medicament for reducing myocardial stunning | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-05 | — | — | EP | disclosed |