SCHEMBL4405587

SCHEMBL4405587

CCOC(=O)c1cnc(SC)nc1NC1CC1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.63
SYK P43405 4/20 0.60
MAPT P10636 6/20 0.57
LMNA P02545 2/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
FOS P01100 1/20 0.57
JUN P05412 1/20 0.57
NFKB1 P19838 1/20 0.57
NFKB2 Q00653 1/20 0.57
RELA Q04206 1/20 0.57
MAPK1 P28482 2/20 0.56
HTT P42858 1/20 0.56
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
NR2F2 P24468 2/20 0.54
NPSR1 Q6W5P4 2/20 0.54
KDM4E B2RXH2 2/20 0.54
NPC1 O15118 1/20 0.53
S1PR2 O95136 1/20 0.53
XBP1 P17861 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29508872 0.95 ALDH1A1 (0.58) ALDH1A1SYKMAPTLMNASMN1; SMN2
SCHEMBL26930605 0.95 ALDH1A1 (0.58) ALDH1A1SYKMAPTLMNASMN1; SMN2
SCHEMBL26930607 0.95 ALDH1A1 (0.58) ALDH1A1SYKMAPTLMNASMN1; SMN2
SCHEMBL22860492 0.95 ALDH1A1 (0.58) ALDH1A1SYKMAPTLMNASMN1; SMN2
SCHEMBL574167 0.95 ALDH1A1 (0.60) ALDH1A1SYKMAPTLMNASMN1; SMN2
SCHEMBL22860692 0.95 ALDH1A1 (0.60) ALDH1A1SYKMAPTLMNASMN1; SMN2
SCHEMBL30498501 0.95 ALDH1A1 (0.60) ALDH1A1SYKMAPTLMNASMN1; SMN2
SCHEMBL4715162 0.94 ALDH1A1 (0.61) ALDH1A1SYKMAPTLMNASMN1; SMN2
SCHEMBL5266863 0.94 ALDH1A1 (0.61) ALDH1A1SYKMAPTLMNASMN1; SMN2
SCHEMBL4157935 0.92 ALDH1A1 (0.57) ALDH1A1SYKMAPTLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025137393-A1 BIFUNCTIONAL COMPOUNDS CONTAINING PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASES 2, 4, AND 6 VIA UBIQUITIN PROTEASOME PATHWAY NIKANG THERAPEUTICS, INC. (US) 2025-06-26 WO disclosed
WO-2023239165-A1 PHENYLSULFONAMIDE DERIVATIVES, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER CONTAINING SAME AS ACTIVE INGREDIENT 한국화학연구원 2023-12-14 WO disclosed
EP-3733184-B1 PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER ICAHN SCHOOL MED MOUNT SINAI (US) 2023-08-30 EP disclosed
EP-3733184-B1 PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER ICAHN SCHOOL MED MOUNT SINAI (US) 2023-08-30 EP disclosed
US-11713309-B2 Solid forms of Cerdulatinib ALEXION PHARMACEUTICALS, INC. (US) 2023-08-01 US disclosed
US-11713309-B2 Solid forms of Cerdulatinib ALEXION PHARMACEUTICALS, INC. (US) 2023-08-01 US disclosed
US-11339145-B2 Synthesis of cerdulatinib ALEXION PHARMACEUTICALS, INC. (US) 2022-05-24 US disclosed
US-20210147392-A1 SYNTHESIS OF CERDULATINIB ALEXION PHARMACEUTICALS, INC. 2021-05-20 US disclosed
US-20210130330-A1 SOLID FORMS OF CERDULATINIB ALEXION PHARMACEUTICALS, INC. 2021-05-06 US disclosed
US-10865198-B2 Solid forms of cerdulatinib ALEXION PHARMACEUTICALS, INC. (US) 2020-12-15 US disclosed
WO-2006003378-A1 AZINE-CARBOXAMIDES AS ANTI-CANCER AGENT ASTRAZENECA AB (SE) 2006-01-12 WO disclosed
EP-1549651-A1 KINASE INHIBITORS Warner-Lambert Company LLC (US) 2005-07-06 EP disclosed
US-20040224958-A1 Pyridopyrimidinone derivatives for treatment of neurodegenerative disease BOOTH RICHARD JOHN (US) 2004-11-11 US disclosed
WO-2004011465-A1 KINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-05 WO disclosed
US-20040019210-A1 Kinase inhibitors CHIVIKAS CONNOLLY CLEO J (US) 2004-01-29 US disclosed
US-6498163-B1 POTENT INHIBITORS OF CYCLIN-DEPENDENT KINASES AND GROWTH FACTOR MEDIATED KINASES; CANCER, RESTENOSIS, ATHEROSCLEROSIS WARNER-LAMBERT COMPANY 2002-12-24 US disclosed
EP-1255755-A1 PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE WARNER-LAMBERT COMPANY (US) 2002-11-13 EP disclosed
WO-2001055148-A1 PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE WARNER-LAMBERT COMPANY (US) 2001-08-02 WO disclosed
EP-0964864-A2 PYRIDO 2,3-D] PYRIMIDINES AND 4-AMINOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION WARNER-LAMBERT COMPANY (US) 1999-12-22 EP disclosed
WO-1998033798-A2 PYRIDO[2,3-D]PYRIMIDINES AND 4-AMINO-PYRIMIDINES AS INHIBITORS OF CELL PROLIFERATION WARNER LAMBERT COMPANY (US) 1998-08-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210130330-A1 SOLID FORMS OF CERDULATINIB CLK1, CLK2, DCLK1 ALDH1A1 4487/4885SYK 1096/4885MAPT 1238/4885
US-20040224958-A1 Pyridopyrimidinone derivatives for treatment of neurodegenerative disease CDK4, CDKL1, CCNT1 ALDH1A1 1162/4885SYK 2342/4885MAPT 2259/4885
US-20040019210-A1 Kinase inhibitors CDK2, CDK1, CDK4 ALDH1A1 1779/4885SYK 369/4885MAPT 3541/4885
US-20210147392-A1 SYNTHESIS OF CERDULATINIB JAK2, DCK, CERS2 ALDH1A1 2168/4885SYK 644/4885MAPT 3748/4885
US-11713309-B2 Solid forms of Cerdulatinib CLK1, CLK2, DCLK1 ALDH1A1 4487/4885SYK 1096/4885MAPT 1238/4885
US-10865198-B2 Solid forms of cerdulatinib CLK1, CLK2, DCLK1 ALDH1A1 4487/4885SYK 1096/4885MAPT 1238/4885
US-11339145-B2 Synthesis of cerdulatinib JAK2, DCK, CERS2 ALDH1A1 2168/4885SYK 644/4885MAPT 3748/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.