Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.54 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4411768 | 1.00 | ACMSD (0.54) | ACMSDELANESERPINE1PTGS2HDAC1 | |
| Bicarbonate SCHEMBL10361427 | 0.98 | ACMSD (0.56) | ACMSDELANESERPINE1PTGS2HDAC1 | |
| SCHEMBL1109740 | 0.92 | ACMSD (0.47) | ACMSDELANESERPINE1PTGS2TDP1 | |
| SCHEMBL1094676 | 0.92 | ACMSD (0.47) | ACMSDELANESERPINE1PTGS2TDP1 | |
| SCHEMBL1094677 | 0.92 | ACMSD (0.47) | ACMSDELANESERPINE1PTGS2TDP1 | |
| SCHEMBL1109744 | 0.92 | ACMSD (0.47) | ACMSDELANESERPINE1PTGS2TDP1 | |
| SCHEMBL8360447 | 0.92 | ACMSD (0.47) | ACMSDELANESERPINE1PTGS2TDP1 | |
| SCHEMBL8356129 | 0.92 | ACMSD (0.47) | ACMSDELANESERPINE1PTGS2TDP1 | |
| SCHEMBL1109745 | 0.92 | ACMSD (0.47) | ACMSDELANESERPINE1PTGS2TDP1 | |
| SCHEMBL8359816 | 0.92 | ACMSD (0.47) | ACMSDELANESERPINE1PTGS2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029541-B1 | PROCESS FOR PREPARATION OF ENANTIOMERICALLY ENRICHED CYCLIC BETA-ARYL OR HETEROARYL CARBOXYLIC ACIDS | HOFFMANN LA ROCHE (CH) | 2009-12-30 | — | — | EP | claimed |