Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2453321 | 0.90 | ABL1 (0.51) | ABL1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2453455 | 0.87 | TRPA1 (0.49) | ABL1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL608664 | 0.85 | ABL1 (0.52) | ABL1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL4407474 | 0.84 | MAPT (0.61) | MEN1KMT2AMAPTALDH1A1MAPK1 | |
| SCHEMBL4420956 | 0.82 | ALDH1A1 (0.53) | MEN1KMT2AMAPTALDH1A1MAPK1 | |
| SCHEMBL4417203 | 0.82 | TRPA1 (0.61) | ABL1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2449783 | 0.80 | TRPA1 (0.60) | ABL1MEN1KMT2ATRPA1 | |
| SCHEMBL2450413 | 0.80 | ABL1 (0.51) | ABL1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL2455704 | 0.80 | ABL1 (0.72) | ABL1MEN1KMT2AMAPTLMNA | |
| SCHEMBL480870 | 0.79 | TRPA1 (0.49) | MEN1KMT2AMAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |