Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2273298 | 0.88 | ALDH1A1 (0.47) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL4406337 | 0.85 | ALDH1A1 (0.45) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL15350813 | 0.84 | KDM4E (0.51) | KDM4EALDH1A1MAPTHTTCYP1A2 | |
| SCHEMBL3909475 | 0.83 | CA12 (0.57) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL2716480 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1TSHRMAPTHTT | |
| SCHEMBL14339199 | 0.83 | ALDH1A1 (0.52) | KDM4EALDH1A1MAPTHTTL3MBTL1 | |
| SCHEMBL978291 | 0.81 | KDM4E (0.71) | KDM4EALDH1A1MAPTHTTCYP1A2 | |
| SCHEMBL15350432 | 0.80 | CYP1A2 (0.54) | KDM4EALDH1A1CYP1A2CYP2C9POLB | |
| SCHEMBL9018717 | 0.79 | ALDH1A1 (0.56) | KDM4EALDH1A1HTTCYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL10754121 | 0.79 | KDM4E (0.69) | KDM4EALDH1A1MAPTHTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589125-B2 | 2-acetoxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic acid; methyl 2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoate; psoriasis and other immune diseases | PALAU PHARMA, S.A. (ES) | 2009-09-15 | — | — | US | claimed |
| US-20050267205-A1 | 2,4-dihydroxybenzoic acid derivatives | J. URIACH Y COMPANIA S.A. (ES) | 2005-12-01 | — | — | US | claimed |
| EP-1546084-A1 | 2,4-DIHYDROXYBENZOIC ACID DERIVATIVES | J. Uriach y Compania S.A. (ES) | 2005-06-29 | — | — | EP | claimed |
| WO-2004009528-A1 | 2,4-DIHYDROXYBENZOIC ACID DERIVATIVES | J. Uriach Y Compañia S.A. (ES) | 2004-01-29 | — | — | WO | claimed |
| EP-2841421-B1 | AMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2019-06-05 | — | — | EP | disclosed |
| US-9701658-B2 | Amide derivatives as TTX-S blockers | RAQUALIA PHARMA INC. (JP) | 2017-07-11 | — | — | US | disclosed |
| US-9701658-B2 | Amide derivatives as TTX-S blockers | RAQUALIA PHARMA INC. (JP) | 2017-07-11 | — | — | US | disclosed |
| US-20150105393-A1 | AMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2015-04-16 | — | — | US | disclosed |
| US-20150105393-A1 | AMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2015-04-16 | — | — | US | disclosed |
| WO-2013161308-A1 | AMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2013-10-31 | — | — | WO | disclosed |
| US-7589125-B2 | 2-acetoxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic acid; methyl 2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoate; psoriasis and other immune diseases | PALAU PHARMA, S.A. (ES) | 2009-09-15 | — | — | US | disclosed |
| US-20050267205-A1 | 2,4-dihydroxybenzoic acid derivatives | J. URIACH Y COMPANIA S.A. (ES) | 2005-12-01 | — | — | US | disclosed |
| EP-1546084-A1 | 2,4-DIHYDROXYBENZOIC ACID DERIVATIVES | J. Uriach y Compania S.A. (ES) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004009528-A1 | 2,4-DIHYDROXYBENZOIC ACID DERIVATIVES | J. Uriach Y Compañia S.A. (ES) | 2004-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105393-A1 | AMIDE DERIVATIVES AS TTX-S BLOCKERS | SCN1B, SCN5A, SCN1A | KDM4E 1198/4885ALDH1A1 2669/4885CA12 3784/4885 |
| US-20050267205-A1 | 2,4-dihydroxybenzoic acid derivatives | CYP24A1, NFKBIA, PAH | KDM4E 638/4885ALDH1A1 101/4885CA12 1530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.