Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10754121 | 0.98 | KDM4E (0.69) | KDM4EALDH1A1CYP2C9CYP1A2POLB | |
| SCHEMBL7032770 | 0.93 | KDM4E (0.63) | KDM4EALDH1A1CYP2C9CYP1A2POLB | |
| SCHEMBL10470177 | 0.91 | ALDH1A1 (0.63) | KDM4EALDH1A1CYP2C9CYP1A2POLB | |
| SCHEMBL10469508 | 0.91 | ALDH1A1 (0.63) | KDM4EALDH1A1CYP2C9CYP1A2POLB | |
| SCHEMBL3876532 | 0.89 | CYP1A2 (0.61) | KDM4EALDH1A1CYP2C9CYP1A2POLB | |
| SCHEMBL10469100 | 0.89 | ALDH1A1 (0.60) | KDM4EALDH1A1CYP2C9CYP1A2POLB | |
| SCHEMBL7694742 | 0.89 | KDM4E (0.73) | KDM4EALDH1A1CYP2C9CYP1A2POLB | |
| SCHEMBL7697964 | 0.88 | KDM4E (0.68) | KDM4EALDH1A1CYP2C9CYP1A2POLB | |
| SCHEMBL10470167 | 0.87 | ALDH1A1 (0.67) | KDM4EALDH1A1CYP2C9CYP1A2POLB | |
| SCHEMBL10470173 | 0.87 | FOLH1 (0.58) | KDM4EALDH1A1CYP2C9CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118541147-B | Novel compound CX-1 and therapeutic use thereof in inflammatory diseases and tumors | 中国医学科学院基础医学研究所 | 2025-04-11 | — | — | CN | claimed |
| CN-118541147-A | Novel compound CX-1 and therapeutic use thereof in inflammatory diseases and tumors | 中国医学科学院基础医学研究所 | 2024-08-23 | — | — | CN | claimed |
| EP-1907360-B1 | IMPROVED PROCESS FOR THE MANUFACTURE OF FLECAINIDE | GLADE ORGANICS PRIVATE LTD (IN) | 2011-03-30 | — | — | EP | claimed |
| US-20100184990-A1 | Process for the Manufacture of Flecainide | GLADE ORGANICS PRIVATE LIMITED (IN) | 2010-07-22 | — | — | US | claimed |
| US-20100056794-A1 | PROCESS FOR THE PREPARATION OF 2,5-BIS-(2,2,2-TRIFLUOROETHOXY)-N-(2-PIPERIDYL-METHYL)-BENZAMIDE AND SALTS THEREOF | GRINDEKS A JOINT STOCK COMPANY (LV) | 2010-03-04 | — | — | US | claimed |
| EP-1907360-A4 | IMPROVED PROCESS FOR THE MANUFACTURE OF FLECAINIDE | GLADE ORGANICS PRIVATE LTD (IN) | 2009-04-01 | — | — | EP | claimed |
| EP-1918280-A1 | Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide and salts thereof | "Joint Stock Company Grindeks" (LV) | 2008-05-07 | — | — | EP | claimed |
| EP-1907360-A1 | IMPROVED PROCESS FOR THE MANUFACTURE OF FLECAINIDE | Glade Organics Private Limited (IN) | 2008-04-09 | — | — | EP | claimed |
| US-7196197-B2 | Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof | APOTEX PHARMACHEM INC. | 2007-03-27 | — | — | US | claimed |
| WO-2007003982-A1 | IMPROVED PROCESS FOR THE MANUFACTURE OF FLECAINIDE | GLADE ORGANICS PRIVATE LIMITED (IN) | 2007-01-11 | — | — | WO | claimed |
| EP-1309538-A2 | METHOD FOR THE PRODUCTION OF TRIFLUOROETHOXY-SUBSTITUTED BENZOIC ACIDS | MERCK PATENT GmbH (DE) | 2003-05-14 | — | — | EP | claimed |
| US-6538138-B1 | Reacting 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid or salt with haloacetonitrile in base presence; amidation, salt formation | FINETECH LTD. (IL) | 2003-03-25 | — | — | US | claimed |
| US-20020133013-A1 | Process for making cyanomethyl ester precursors of flecainide | FINETECH LTD. | 2002-09-19 | — | — | US | claimed |
| WO-2002066413-A1 | FLECAINIDE SYNTHESIS | NARCHEM CORPORATION (US) | 2002-08-29 | — | — | WO | claimed |
| WO-2001090062-A2 | METHOD FOR THE PRODUCTION OF TRIFLUOROETHOXY-SUBSTITUTED BENZOIC ACIDS | MERCK PATENT GMBH (DE) | 2001-11-29 | — | — | WO | claimed |
| US-6316627-B1 | REACTING A HALOBENZOIC ACID OR ITS SALT WITH WITH 2,2,2-TRIFLUOROETHANOL IN THE PRESENCE OF A STRONG BASE AND COPPER OR A COPPER COMPOUND OR ALLOY, IF DESIRED FOLLOWED BY ACIDIFICATION; CONVERTING TO FLECAINIDE OR ITS SALT | FINE TECH LTD. (IL) | 2001-11-13 | — | — | US | claimed |
| EP-0996616-A1 | PROCESS AND A NOVEL INTERMEDIATE FOR THE PREPARATION OF FLECAINIDE | Finetech Ltd (IL) | 2000-05-03 | — | — | EP | claimed |
| WO-1999002498-A1 | PROCESS AND A NOVEL INTERMEDIATE FOR THE PREPARATION OF FLECAINIDE | FINETECH LTD. (IL) | 1999-01-21 | — | — | WO | claimed |
| US-4684733-A | Process for the preparation of intermediates of derivatives of pyrrolidine and piperidine | RIKER LABORATORIES, INC. (US) | 1987-08-04 | — | — | US | claimed |
| US-4617396-A | Process for the preparation of derivatives of piperidine | RIKER LABORATORIES, INC. (US) | 1986-10-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056794-A1 | PROCESS FOR THE PREPARATION OF 2,5-BIS-(2,2,2-TRIFLUOROETHOXY)-N-(2-PIPERIDYL-METHYL)-BENZAMIDE AND SALTS THEREOF | BOLA2; BOLA2B, TET2, CYP1A2 | KDM4E 429/4885ALDH1A1 430/4885CYP2C9 181/4885 |
| US-20020133013-A1 | Process for making cyanomethyl ester precursors of flecainide | CA2, KCNH1, SCN1B | KDM4E 1366/4885ALDH1A1 251/4885CYP2C9 40/4885 |
| US-20100184990-A1 | Process for the Manufacture of Flecainide | KCND2, KCNH1, KCNH2 | KDM4E 478/4885ALDH1A1 960/4885CYP2C9 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.