Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.54 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | NEK2 | P51955 | 2/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.49 |
| ▸ | STK3 | Q13188 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.49 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.49 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.49 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.49 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5003083 | 0.85 | PLK1 (0.65) | PLK1PLK3KDRNEK2SLK | |
| SCHEMBL14029665 | 0.79 | PLK1 (0.71) | PLK1PLK3KDRNEK2SLK | |
| Trifluoroacetic Acid SCHEMBL5003812 | 0.79 | PLK1 (0.64) | PLK1PLK3KDRNEK2SLK | |
| SCHEMBL6214432 | 0.77 | PLK1 (0.84) | PLK1PLK3MAP4K4CSF1RKDR | |
| SCHEMBL6214929 | 0.76 | PLK1 (0.68) | PLK1PLK3MAP4K4CSF1RKDR | |
| SCHEMBL6210332 | 0.75 | PLK1 (0.56) | PLK1PLK3NEK2 | |
| Trifluoroacetic Acid SCHEMBL4405442 | 0.74 | PLK1 (0.66) | PLK1PLK3KDRNEK2SLK | |
| Trifluoroacetic Acid SCHEMBL4999376 | 0.74 | PLK1 (0.63) | PLK1PLK3KDRNEK2SLK | |
| SCHEMBL14029654 | 0.74 | PLK1 (0.69) | PLK1PLK3KDRNEK2PIM1 | |
| Trifluoroacetic Acid SCHEMBL4398141 | 0.73 | PLK1 (0.64) | PLK1PLK3KDRNEK2SLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-B1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORP (US) | 2009-12-30 | — | — | EP | disclosed |