SCHEMBL4408950

SCHEMBL4408950

O=C(Cc1nccn1Cc1ccccc1)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.52
ALDH1A1 P00352 1/20 0.49
HSP90AB1 P08238 1/20 0.46
HSP90B1 P14625 1/20 0.46
OPRD1 P41143 2/20 0.46
OPRK1 P41145 1/20 0.46
AGTR1 P30556 1/20 0.46
AGTR2 P50052 1/20 0.46
FDPS P14324 1/20 0.45
HDAC1 Q13547 1/20 0.45
MAPT P10636 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
ADRB1 P08588 1/20 0.44
ADRB3 P13945 1/20 0.44
POLB P06746 1/20 0.44
HPGD P15428 1/20 0.44
HTT P42858 1/20 0.44
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4851345 0.86 HSP90AA1 (0.56) HSP90AA1ALDH1A1HSP90AB1HSP90B1OPRD1
SCHEMBL4412889 0.86 NPC1 (0.45) HSP90AA1ALDH1A1MEN1KMT2A
Hydrochloric Acid SCHEMBL9715416 0.85 HSP90AA1 (0.55) HSP90AA1ALDH1A1HSP90AB1HSP90B1OPRD1
SCHEMBL5722028 0.85 ALPG (0.50) FDPSL3MBTL1POLB
SCHEMBL955143 0.82 HSP90AA1 (0.57) HSP90AA1ALDH1A1HSP90AB1HSP90B1AGTR1
Hydrochloric Acid SCHEMBL954438 0.81 HSP90AA1 (0.56) HSP90AA1ALDH1A1HSP90AB1HSP90B1AGTR1
SCHEMBL1051652 0.79 ALDH1A1 (0.54) HSP90AA1ALDH1A1HSP90AB1HSP90B1OPRD1
SCHEMBL21208597 0.78 OPRM1 (0.51) HSP90AA1ALDH1A1HSP90AB1HSP90B1OPRD1
SCHEMBL2872636 0.78 HSP90AA1 (0.60) HSP90AA1ALDH1A1HSP90AB1HSP90B1AGTR1
SCHEMBL2872632 0.78 HSP90AA1 (0.56) HSP90AA1ALDH1A1HSP90AB1HSP90B1AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009115392-A1 IMIDAZOLIUM SALTS AS ENZYME STABILIZERS HENKEL AG & CO. KGAA (DE) 2009-09-24 WO disclosed