Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 5/20 | 0.49 |
| ▸ | RAF1 | P04049 | 4/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551497 | 0.92 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5484374 | 0.92 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL4727385 | 0.89 | RAF1 (0.56) | MAPK14BRAFRAF1 | |
| SCHEMBL4551653 | 0.89 | DDR2 (0.55) | MAPK14MAPK13MAPK12MAPK11PDE4B | |
| SCHEMBL4411010 | 0.86 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL4418530 | 0.85 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4417663 | 0.85 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL4551755 | 0.85 | PLAU (0.48) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL14534471 | 0.84 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11PDE4B | |
| SCHEMBL4409138 | 0.84 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |