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SCHEMBL5484374

SCHEMBL5484374

COc1ccc(OC(=O)c2cc(NC(=O)c3cc(F)cc(N4CCOCC4)c3)cnc2C)cc1

nearest known ligand 0.51

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 12/20 0.51
▸ MAPK13 O15264 1/20 0.48
▸ MAPK12 P53778 1/20 0.48
▸ MAPK11 Q15759 1/20 0.48
▸ PLAU P00749 1/20 0.47
▸ BRAF P15056 6/20 0.46
▸ RAF1 P04049 5/20 0.46
▸ CSF1R P07333 1/20 0.45
▸ DAPK1 P53355 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4409060 0.92 MAPK14 (0.54) MAPK14MAPK13MAPK12MAPK11PLAU
SCHEMBL5499408 0.89 DDR2 (0.54) MAPK14MAPK13MAPK12MAPK11PLAU
SCHEMBL4727385 0.87 RAF1 (0.56) MAPK14BRAFRAF1
SCHEMBL4551497 0.84 MAPK14 (0.60) MAPK14MAPK13MAPK12MAPK11PLAU
SCHEMBL15074587 0.81 PLAU (0.57) MAPK14MAPK13MAPK12MAPK11PLAU
SCHEMBL4551653 0.81 DDR2 (0.55) MAPK14MAPK13MAPK12MAPK11PLAU
SCHEMBL4781713 0.80 MAPK14 (0.53) MAPK14BRAFRAF1
SCHEMBL5593401 0.79 PLAU (0.48) MAPK14MAPK13MAPK12MAPK11PLAU
SCHEMBL5593395 0.79 PLAU (0.48) MAPK14MAPK13MAPK12MAPK11PLAU
SCHEMBL4551755 0.79 PLAU (0.48) MAPK14MAPK13MAPK12MAPK11PLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007056016-A2 BISAMIDE CYTOKINE INHIBITORS KEMIA, INC. (US) 2007-05-18 — — WO disclosed